EST73502
EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity.
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- No. CAS: 1838622-25-5
- Fòrmula: C19H26F2N2O2
- Peso molecular:352.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Opioid Receptor
MoreVer todos los productos específicos de isoformas Sigma Receptor
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Actividad biológica
Ki: 64 nM (MOR), 118 nM (σ1R)[1]
EST73502 (5 mg/kg; i.p.; twice a day; for 10 days) attenuates partial sciatic nerve ligation (PSNL)-induced mechanical allodynia in male CD1 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD1 mice, PSNL model[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection, twice a day, for 10 days
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Result:Attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%.
Chemical Information
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No. CAS 1838622-25-5
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Peso molecular 352.42
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Fòrmula C19H26F2N2O2
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SMILES
FC1=CC=C(F)C=C1CCN(CC2)CCC2(O[C@@H]3C)CN(CC)C3=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EST73502 Related Classifications
HY-134189 Related Classifications
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