EXP631
EXP631 is a centrally acting non-opioid analgesic that targets serotonin and norepinephrine transporters. EXP631 exhibits activity against acute pain induced by chemical stimuli, stress, and electrical stimulation. EXP631 blocks the reuptake of serotonin and norepinephrine. EXP631 can be used in research related to moderate to moderately severe acute and chronic pain.
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- No. CAS: 151656-58-5
- Fòrmula: C13H21NOS·1/2C4H4O4
- Peso molecular:297.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
EXP631 is isolated and structurally identified in rat plasma, confirming its conversion to the N-demethylated metabolite (II). The EI mass spectrum of this metabolite shows a molecular ion peak at m/z 225, and the [M+H]+ peak in its NH3-CI mass spectrum is at m/z 226[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | Cmax | Tmax | AUC | T1/2 | Bioavailability | CL | V | Vd |
|---|---|---|---|---|---|---|---|---|---|---|
| Rat[1] | 5.0 mg/kg | i.v. | / | / | 1.11 μg·h/mL | 1.06 h | / | 3.67 L/h/kg | / | 5.63 L/kg |
| Rat[1] | 5.0 mg/kg | p.o. | 0.94 μg/mL | 0.31 h | 1.05 μg·h/mL | 1.44 h | 92 % | / | / | / |
| Rat[1] | 10.0 mg/kg | p.o. | 1.07 μg/mL | 0.75 h | 2.62 μg·h/mL | 1.51 h | 117 % | / | / | / |
| Rat[1] | 20.0 mg/kg | p.o. | 2.26 μg/mL | 1.19 h | 5.84 μg·h/mL | 1.99 h | 131 % | / | / | / |
| Dog[1] | 3.0 mg/kg | i.v. | / | / | 3.14 μg·h/mL | 2.48 h | / | 0.77 L/h/kg | 2.77 L/kg | / |
| Dog[1] | 10.0 mg/kg | p.o. | 2.46 μg/mL | 0.33 h | 8.46 μg·h/mL | 3.49 h | 81 % | / | / | / |
| Dog[1] | 8.0 mg/kg | i.v. | / | / | 10.68 μg·h/mL | 2.58 h | / | 0.62 L/h/kg | 2.29 L/kg | / |
| Dog[1] | 8.0 mg/kg | p.o. | 2.05 μg/mL | 1.38 h | 12.11 μg·h/mL | 5.53 h | 115 % | / | / | / |
Chemical Information
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No. CAS 151656-58-5
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Peso molecular 297.42
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Fòrmula C13H21NOS·1/2C4H4O4
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SMILES
OC(/C=C\C(O)=O)=O.CC(O)(C1(C2=CSC=C2)CCN(CC1)C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EXP631 Related Classifications
HY-183420 Related Classifications
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Keywords
- EXP631
- 151656-58-5
- EXP 631
- EXP-631
- Serotonin Transporter
- Monoamine Transporter
- animal models
- pressure-induced pain
- serotonin reuptake
- chronic pain
- serotonin transporters
- norepinephrine reuptake
- acute pain
- acute chemically induced pain
- norepinephrine transporters
- electrical-stimulation pain
- Inhibitor
- inhibitor
- inhibit