FR20
FR20 acts as an inhibitor of human microsomal prostaglandin synthase 1 (mPGES 1).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 570373-45-4
- Fòrmula: C31H25Cl2N3O2
- Peso molecular:542.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.13 μM
Compound: 7, FR20
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Inhibition of mPGES-1 derived from IL1beta and TNFalpha stimulated human HeLa cells microsomal fraction using PGH2 as substrate preincubated for 30 mins prior to substrate addition measured after 1 min by LC-MS/MS analysis
Inhibition of mPGES-1 derived from IL1beta and TNFalpha stimulated human HeLa cells microsomal fraction using PGH2 as substrate preincubated for 30 mins prior to substrate addition measured after 1 min by LC-MS/MS analysis
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[PMID: 22449023] |
| HeLa | IC50 |
0.5 μM
Compound: 18
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Inhibition of mPGES1 expressed in human HeLa cells assessed as inhibition of IL-1-beta/TNF-alpha-induced PGE2 production by Western blot analysis
Inhibition of mPGES1 expressed in human HeLa cells assessed as inhibition of IL-1-beta/TNF-alpha-induced PGE2 production by Western blot analysis
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[PMID: 20025212] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 570373-45-4
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Peso molecular 542.46
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Fòrmula C31H25Cl2N3O2
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SMILES
O=C(C1=CC=CC=C1Cl)NC2=CC3=C(C=C2)N=C(N(C3=O)CC4=CC=C(C=C4)C5=CC=CC(Cl)=C5)CCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR20 Related Classifications
HY-122064 Related Classifications
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