GATT-44
GATT-44 is a blood-brain barrier-permeable, selective GABA transporter 1 (GAT-1) ligand with an IC50 of 126 nM. GATT-44 shows selectivity for GAT-2, GAT-3 and BGT-1 subtypes, and undergoes copper-mediated 18F-radiofluorination. The radiolabeled GATT-44 ([18F]GATT-44) exhibits brain uptake, metabolic stability and high GAT-1 binding specificity in non-human primates. GATT-44 is applicable for research on neurodegenerative and neuropsychiatric diseases.
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- No. CAS: 1265900-99-9
- Fòrmula: C23H26FNO2
- Peso molecular:367.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
GATT-44 potently inhibits GAT-1 binding in rat brain slices with an IC50 of <100 nM[1].
GATT-44 (50 μM) selectively inhibits GAT-1 in transfected cells with an IC50 of 126 nM, with no activity against GAT-2, GAT-3, or BGT-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1265900-99-9
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Peso molecular 367.46
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Fòrmula C23H26FNO2
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SMILES
FC1=C(/C(C2=CC=CC=C2C)=C/CCN3C[C@@H](CCC3)C(O)=O)C=CC=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GATT-44 Related Classifications
HY-182944 Related Classifications
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