B2M - beta-2-microglobulin Gene
Also Known as IMD43
Species: Homo sapiens
About B2M
This gene has 12 transcripts (splice variants), 1 gene allele, 149 orthologues, 13 paralogues and is associated with 78 phenotypes. Ubiquitous expression in spleen (RPKM 1527.0), lymph node (RPKM 1335.3) and 24 other tissues.
Summary
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays Antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
B2M Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004048.4 | NP_004039.1 | beta-2-microglobulin precursor |
| Molecular Function GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
17108084 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9427624 | GOA |
| enables protein homodimerization activity |
IPI
IPI: Inferred from physical interaction
|
28468825 | GOA |
| enables structural molecule activity |
IDA
IDA: Inferred from direct assay
|
36104323 | GOA |
| Cellular Component GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| part of HFE-transferrin receptor complex |
IDA
IDA: Inferred from direct assay
|
9990067 | GOA |
| part of MHC class I peptide loading complex |
IDA
IDA: Inferred from direct assay
|
21263072 | GOA |
B2M Protein Structure
C1-set: Immunoglobulin C1-set domain (32 - 111)
- 0
- 100
- 119 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
beta-2-microglobulin |
|
B2M Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Referencias |
|---|---|---|---|---|---|---|---|
|
Intra
|
B2M | P61769 | HFE | Homo sapiens | Q30201 | 33961781 | |
|
Intra
|
B2M | P61769 | HFE | Homo sapiens | Q30201 | 15965644 | |
|
Intra
|
B2M | P61769 | HFE | Homo sapiens | Q30201 | 20618438 | |
|
Intra
|
B2M | P61769 | CD1B | Homo sapiens | P29016 | 12118248 | |
|
Intra
|
B2M | P61769 | CD1A | Homo sapiens | P06126 | 12833155 | |
|
Intra
|
B2M | P61769 | CD1A | Homo sapiens | P06126 | 15723809 | |
|
Intra
|
B2M | P61769 | CD244 | Homo sapiens | Q9BZW8 | 20164429 | |
|
Intra
|
B2M | P61769 | HLA-A | Homo sapiens | P01892 | 11502003 | |
|
Intra
|
B2M | P61769 | PYGO1 | Homo sapiens | Q9Y3Y4 | 32814053 | |
|
Intra
|
B2M | P61769 | PYGO1 | Homo sapiens | Q9Y3Y4 | 32814053 | |
|
Intra
|
B2M | P61769 | PYGO1 | Homo sapiens | Q9Y3Y4 | 32814053 | |
|
Intra
|
B2M | P61769 | PCNA | Homo sapiens | P12004 | 23527218 | |
|
Intra
|
B2M | P61769 | PCNA | Homo sapiens | P12004 | 26030842 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19172750 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19564620 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 21131979 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 18579777 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 21131979 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 21131979 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19564620 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 17108084 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 21131979 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 17108084 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19172750 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19172750 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 21131979 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 21220305 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19564620 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 18579777 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 20826442 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19564620 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19564620 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 19172750 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 17108084 | |
|
Intra
|
B2M | P61769 | B2M | Homo sapiens | P61769 | 20826442 |
Recombinant B2M Proteins
B2M Antibodies
| Referencia número | Nombre del producto | Aplicación | Reactivity |
|---|---|---|---|
| HY-P81260 | beta 2 Microglobulin Antibody (YA934) | ELISA | Human |
| HY-P81260A | beta 2 Microglobulin Antibody (YA935) | WB, IP | Human, Mouse, Rat |
| HY-P81260AA | beta 2 Microglobulin Antibody (YA935)(PBS only) | WB, IP | Human, Mouse, Rat |
| HY-P86752 | beta 2 Microglobulin Antibody (YA6444) | WB | Human |
| HY-P86752A | beta 2 Microglobulin Antibody (YA6444)(PBS only) | WB | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Immunodeficiency 43 |
|
|
| Amyloidosis, Familial Visceral |
|
|
| Dialysis-Related Amyloidosis |
|
|
| Immunodeficiency By Defective Expression Of Mhc Class I |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Amyloidosis |
|
|
| Urinary System Disease |
|
|
| Carpal Tunnel Syndrome |
|
|
| Danubian Endemic Familial Nephropathy |
|
|
| Lung Oat Cell Carcinoma |
|
|
| Plasma Cell Neoplasm |
|
|
| Acute Kidney Failure |
|
|
| Ovarian Serous Cystadenocarcinoma |
|
|
| Kidney Disease |
|
|
| Uremia |
|
|
| Mercury Poisoning |
|
|
| Arthropathy, Erosive |
|
|
| Chronic Pyelonephritis |
|
|
| Renal Tuberculosis |
|
|
| Myeloma, Multiple |
|
|
| Plasmacytoma |
|
|
| Small Cell Cancer Of The Lung |
|
|
| Bone Disease |
|
|
| Peritonitis |
|
|
| Paget'S Disease Of Bone |
|
|
| Aids Dementia Complex |
|
|
| Skin Melanoma |
|
|
| Amyloid Tumor |
|
|
| Syphilis |
|
|
| Gastric Adenocarcinoma |
|
|
| Pleural Tuberculosis |
|
|
| Lung Squamous Cell Carcinoma |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Serum Amyloid A Amyloidosis |
|
|
| Non-Secretory Myeloma |
|
|
| Secondary Hyperparathyroidism |
|
|
| Nerve Compression Syndrome |
|
|
| Hydronephrosis |
|
|
| Urinary Tract Obstruction |
|
|
| Nephrotic Syndrome |
|
|
| Hemochromatosis, Type 1 |
|
|
| Solitary Bone Cyst |
|
|
| Meningoencephalitis |
|
|
| Arthropathy |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Spondylarthropathy |
|
|
| Hereditary Amyloidosis |
|
|
| Renal Tubular Acidosis |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Glomerulonephritis |
|
|
| Uremic Neuropathy |
|
|
| Oral Candidiasis |
|
|
| Sjogren Syndrome |
|
|
| Extramedullary Plasmacytoma |
|
|
| Osteitis Fibrosa |
|
|
| Monoclonal Gammopathy Of Uncertain Significance |
|
|
| Immunoglobulin Light Chain Amyloidosis |
|
|
| Vesicoureteral Reflux |
|
|
| Smoldering Myeloma |
|
|
| Intermittent Claudication |
|
|
| Human Immunodeficiency Virus Type 1 |
|
|
| Lung Cancer |
|
|
| Solitary Osseous Plasmacytoma |
|
|
| Aminoaciduria |
|
|
| Viral Meningitis |
|
|
| Immune Deficiency Disease |
|
|
| Wild-Type Amyloidosis |
|
|
| Arthritis |
|
|
| Chronic Kidney Disease |
|
|
| Blood Protein Disease |
|
|
| Reticulosarcoma |
|
|
| Pyuria |
|
|
| Infected Hydrocele |
|
|
| Multicentric Carpotarsal Osteolysis Syndrome |
|
|
| Beta-Thalassemia |
|
|
| Skin Disease |
|
|
| Amyloidosis, Hereditary, Transthyretin-Related |
|
|
| Burkitt Lymphoma |
|
|
| Interstitial Nephritis |
|
|
| Monoclonal Paraproteinemia |
|
|
| Lymphoplasmacytic Lymphoma |
|
|
| Extrinsic Allergic Alveolitis |
|
|
| Orthostatic Proteinuria |
|
|
| Spondyloarthropathy |
|
|
| Lymphoid Interstitial Pneumonia |
|
|
| Viral Infectious Disease |
|
|
| Deficiency Anemia |
|
|
| Myeloproliferative Neoplasm |
|
|
| Plasma Cell Leukemia |
|
|
| Spondyloepiphyseal Dysplasia, Sensorineural Hearing Loss, Impaired Intellectual Development, And Leber Congenital Amaurosis |
|
|
| Bare Lymphocyte Syndrome, Type I |
|
|
| Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency |
|
|
| Bone Marrow Cancer |
|
|
| Acute Kidney Tubular Necrosis |
|
|
| Intestinal Pseudo-Obstruction |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism |
|
|
| Pulmonary Coin Lesion |
|
|
| Plasma Protein Metabolism Disease |
|
|
| Malaria |
|
|
| B-Cell Expansion With Nfkb And T-Cell Anergy |
|
|
| Fanconi Syndrome |
|
|
| Pyelitis |
|
|
| Mature B-Cell Neoplasm |
|
|
| Leukocyte Disease |
|
|
| Heart Disease |
|
|
| Mineral Metabolism Disease |
|
|
| Autoimmune Disease |
|
|
| Waldenstroem'S Macroglobulinemia |
|
|
| Rheumatoid Arthritis |
|
|
| Potocki-Shaffer Syndrome |
|
|
| Pulmonary Plasma Cell Granuloma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Macroglossia |
|
|
| Type 1 Diabetes Mellitus |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Diabetes Mellitus |
|
|
| Asymmetric Motor Neuropathy |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Inflammatory Bowel Disease |
|
|
| Osteoporosis |
|
|
| Hypertension, Essential |
|
|
| Cystic Basal Cell Carcinoma |
|
|
| Beta-Thalassemia Major |
|
|
| Bronchiectasis 3 |
|
|
| Mantle Cell Lymphoma |
|
|
| Peripheral Nervous System Disease |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | B2M | MGD | MGI:88127 |
| Canis familiaris | B2M | VGNC | VGNC:38331 |
| Felis catus | B2M | VGNC | VGNC:68927 |
| Macaca mulatta | B2M | VGNC | VGNC:70203 |
| Rattus norvegicus | B2M | RGD | RGD:2189 |
| Others | B2M | NCBI |