GR 82334
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.
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- No. CAS: 129623-01-4
- Fòrmula: C69H91N15O16
- Peso molecular:1386.55
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2]
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Dosage:10 nM, 100 nM, and 1 µM
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Administration:Lntrathecal injection between vertebrae L4 and L5
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Result:Increased heat-induced foot withdrawal latency in mice.
Chemical Information
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No. CAS 129623-01-4
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Peso molecular 1386.55
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Fòrmula C69H91N15O16
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Sequence
{Glp}-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-{d-Pro(spiro-γ-lactam)Leu}-Trp-NH2
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Sequence Shortening
{Glp}-ADPNKFY-{d-Pro(spiro-γ-lactam)Leu}-W-NH2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci [Content Brief]
[2]. Antje Brand, et al. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GR 82334 Related Classifications
HY-P1193 Related Classifications
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