GSC-718
GSC-718 is a CD22 inhibitor with an IC50 of 0.161 μM against mouse CD22. GSC-718 competitively blocks the binding of mouse CD22 to natural glycan ligands, and inhibits the interaction between CD22 and α2,6-sialylated ligands. GSC-718 promotes B cell proliferation and enhances antibody production. GSC-718 can be used in the research of B cell lymphoma and rheumatoid arthritis.
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- No. CAS: 2493080-16-1
- Fòrmula: C32H35N2NaO11
- Peso molecular:646.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
GSC-718 (2 hours) potently inhibits recombinant mouse CD22-Fc binding to biotinylated sialoside 71 in a competitive ELISA with an IC50 of 0.161 µM[1].
GSC-718 significantly enhances B cell proliferation induced by various stimuli including toll-like receptor ligands[1].
GSC-718 (10-100 μM; 10 min) partially inhibits proximity labeling of CD22-associated proteins on wild-type mouse spleen B cells, while GSC-932 achieves near-complete inhibition under the same conditions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Collagen-Induced Arthritis
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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No. CAS 2493080-16-1
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Peso molecular 646.62
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Fòrmula C32H35N2NaO11
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SMILES
O=C(O[Na])[C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(CO)=O)([H])[C@H](O)[C@H](O)CNC(CC2=CC=C(C3=CC=C(C=C3)O)C=C2)=O)OCC4=CC=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSC-718 Related Classifications
HY-171172 Related Classifications
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