HOE-288
HOE-288 is an orally active angiotensin-converting enzyme (ACE) inhibitor. HOE-288 can be used for the research of neurological disease.
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- No. CAS: 93231-79-9
- Fòrmula: C27H38N2O5
- Peso molecular:470.60
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
HOE-288 (10 mg/kg, i.g., daily for 1 weeks) results in a marked inhibition of CE activity in the brain cortex, the hypothalamus, and in the brainstem in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 93231-79-9
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Peso molecular 470.60
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Fòrmula C27H38N2O5
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SMILES
O=C(C1N(CC2(CC3CCC2CC3)C1)C(C(C)NC(CCC4=CC=CC=C4)C(OCC)=O)=O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Dennes RP, et al. Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze. Psychopharmacology (Berl). 1993;111(4):435-41. [Content Brief]
[2]. Gohlke P, et al. Inhibition of converting enzyme in brain tissue and cerebrospinal fluid of rats following chronic oral treatment with the converting enzyme inhibitors ramipril and Hoe 288. J Cardiovasc Pharmacol. 1989;14 Suppl 4:S32-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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