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Referencia número: HY-19557

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IDX-320

IDX-320 is a Pipecolic acid (HY-Y0669) derivative. IDX-320 inhibits NS3/4a proteases across genotypes 1a, 1b, 2a, and 4a with an IC₅₀ 0.8-1.9 nM. IDX-320 can be used in the research of HCV infection.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1251165-81-7
Fòrmula: C₃₇H₄₃F₃N₆O₇S₂
Peso molecular:804.90

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

IDX-320 Chemical Structure

No. CAS: 1251165-81-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- Ensayo clínico
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

IC₅₀: 0.8-1.9 nM (NS3/4a proteases across genotypes 1a, 1b, 2a, and 4a)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	CC₅₀	>10 μM Compound: 8; IDX320	Cytotoxicity against human hepatocytes Cytotoxicity against human hepatocytes	[PMID: 26410074]
Huh-7	CC₅₀	52.78 μM Compound: 8; IDX320	Cytotoxicity against human HuH7 cells by colorimetric proliferation assay Cytotoxicity against human HuH7 cells by colorimetric proliferation assay	[PMID: 26410074]
Huh-7	EC₅₀	0.7 nM Compound: 8; IDX320	Antiviral activity against HCV genotype 1b infected in human HuH7 cells after 3 days by luciferase assay Antiviral activity against HCV genotype 1b infected in human HuH7 cells after 3 days by luciferase assay	[PMID: 26410074]

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 1251165-81-7
Peso molecular 804.90
Fòrmula C₃₇H₄₃F₃N₆O₇S₂
SMILES

O=C(NS(=O)(C1(CC1)C)=O)[C@]23NC([C@@](C[C@@H](OC4=CC(C5=NC(C(F)(F)F)=CS5)=NC6=C(C)C(OC)=CC=C46)CC7)([H])N7C(N(C)CCCC/C=C\[C@]2([H])C3)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Liverton N J. Evolution of HCV NS3/4a Protease Inhibitors[M]//HCV: The Journey from Discovery to a Cure: Volume I. Cham: Springer International Publishing, 2019: 231-259.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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