ISD sodium
Based on 4 publication(s) in Google Scholar
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the cGAS‑STING‑TBK1‑IRF3 pathway.
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- Pureza : 98.02%
- Peso molecular:27674.92 (free acid)
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) ISD sodium
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Actividad biológica
Descripciòn
In Vitro
ISD (2 μg/mL; 2-4 h) sodium activates the cGAS-STING pathway in bone marrow-derived macrophages, promotes the phosphorylation of STING and IRF3, and upregulates the mRNA expression of IFN-β, TNF-α, IL-6 and CXCL10[1].
ISD (8 μg per well; 6 h) sodium induces IFNB promoter activity mediated by the cGAS-STING signaling pathway in HeLa cells[2].
ISD (8 μg per well; 6 h) sodium induces the mRNA expression of Ifna4, Ifnb, Isg15 and Rsad2 in L929 cells/mouse bone marrow-derived macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L929 murine fibroblast cells
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Concentration:8 μg per well
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Incubation Time:6 h
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Result:Triggered induction of Ifna4, Ifnb, Isg15, and Rsad2 mRNA in L929 cells.
Chemical Information
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Appearance Solid
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Peso molecular 27674.92 (free acid)
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Color White to off-white
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SMILES
[ISD (sodium)]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
RNF213 Is an Interferon-Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection. [Abstract]2026 Mar 18:e11012. PMID: 41849692 -
Chin Herb Med
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. [Abstract]2024 Apr 30;16(3):422-434. PMID: 39072201 -
Int Immunopharmacol
2025 Feb 6:147:114014. PMID: 39793225 -
Immunopharmacol Immunotoxicol
Dichapetalin-type triterpenoids inhibits macrophage interferon expression by regulating the cGas-STING pathway, suggesting potential application in immunosuppression. [Abstract]2025 Aug;47(4):517-524. PMID: 40443028
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2242 KB)
Referencias
[1]. Li J, et al. Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. Chin Herb Med. 2024 Apr 30;16(3):422-434. [Content Brief]
[2]. Xu L, et al. Laminaran potentiates cGAS-STING signaling to enhance antiviral responses. Int Immunopharmacol. 2025;147:114014. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ISD sodium Related Classifications
HY-160225 Related Classifications
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