Leucomentin-5
Leucomentin-5 is a free radical scavenger. Leucomentin-5 has strong inhibitory effect of lipid peroxidation with IC50 of 0.11 μg/mL.
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- No. CAS: 300662-10-6
- Fòrmula: C38H34O13
- Peso molecular:698.67
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 300662-10-6
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Peso molecular 698.67
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Fòrmula C38H34O13
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SMILES
C[C@H](O1)[C@H]1/C=C\C(OC2=C(C3=CC=C(C=C3)O)C(OC(/C=C\[C@@H]4[C@@H](O4)C)=O)=C(C(C5=CC=C(C=C5)O)=C2OC(/C=C\[C@@H]6[C@@H](O6)C)=O)OC(C)=O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Ferroptosis Solutions
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death characterized by lethal lipid peroxidation and sensitivity to suppression by iron chelators or lipophilic radical-trapping antioxidants. The core pathway links cystine uptake through system Xc−, glutathione availability, GPX4-dependent detoxification of phospholipid hydroperoxides, iron-dependent oxidative reactions, and polyunsaturated-phospholipid metabolism into a cell-death program that is biochemically and morphologically distinct from apoptosis, necrosis, and autophagy. The ferroptosis pathway is experimentally linked to phenotype through chemical and genetic perturbation. Erastin induces ferroptosis by inhibiting cystine uptake through system Xc− and weakening antioxidant defenses, while GPX4 inhibition or depletion causes lipid peroxide accumulation and ferroptotic cancer-cell death. ACSL4 and oxidizable arachidonoyl- or adrenoyl-containing phosphatidylethanolamines shape ferroptosis sensitivity by con
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Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leucomentin-5 Related Classifications
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