MDL 101146
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 149859-17-6
- Fòrmula: C29H37F5N4O6
- Peso molecular:632.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Ki for neutrophil elastase: 25 nM (human); 18 nM (rat)[1][2]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[2]
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Dosage:200 mg/kg
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Administration:Oral, 200 mg/kg/day
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Result:Inhibited the severity of collagen-induced arthritis.
Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.
Chemical Information
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No. CAS 149859-17-6
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Peso molecular 632.62
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Fòrmula C29H37F5N4O6
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SMILES
O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl [Content Brief]
[2]. M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDL 101146 Related Classifications
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