MenA-IN-2
Based on 1 Customer Validation
MenA-IN-2 (Compound 11) is an inhibitor of 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA). MenA-IN-2 inhibits MenA with an IC50 value of 22 µM and inhibits Mycobacterium tuberculosis (Mtb) with an GIC50 value of 10 µM. MenA-IN-2 can curb the continuous transmission of Mtb.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.84%
- No. CAS: 3026690-49-0
- Fòrmula: C23H31ClN2O
- Peso molecular:386.96
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
IC50: 22 µM (1,4-dihydroxy-2-naphthoate prenyltransferase, MenA)[1]
Chemical Information
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No. CAS 3026690-49-0
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Appearance Solid
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Peso molecular 386.96
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Fòrmula C23H31ClN2O
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Color White to off-white
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SMILES
CCCN(C1=CC=C(C=C1)CN2CCC(CC2)COC3=CC=C(C=C3)Cl)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 250 mg/mL (646.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5842 mL | 12.9212 mL | 25.8425 mL | 64.6062 mL |
| 5 mM | 0.5168 mL | 2.5842 mL | 5.1685 mL | 12.9212 mL | |
| 10 mM | 0.2584 mL | 1.2921 mL | 2.5842 mL | 6.4606 mL | |
| 15 mM | 0.1723 mL | 0.8614 mL | 1.7228 mL | 4.3071 mL | |
| 20 mM | 0.1292 mL | 0.6461 mL | 1.2921 mL | 3.2303 mL | |
| 25 mM | 0.1034 mL | 0.5168 mL | 1.0337 mL | 2.5842 mL | |
| 30 mM | 0.0861 mL | 0.4307 mL | 0.8614 mL | 2.1535 mL | |
| 40 mM | 0.0646 mL | 0.3230 mL | 0.6461 mL | 1.6152 mL | |
| 50 mM | 0.0517 mL | 0.2584 mL | 0.5168 mL | 1.2921 mL | |
| 60 mM | 0.0431 mL | 0.2154 mL | 0.4307 mL | 1.0768 mL | |
| 80 mM | 0.0323 mL | 0.1615 mL | 0.3230 mL | 0.8076 mL | |
| 100 mM | 0.0258 mL | 0.1292 mL | 0.2584 mL | 0.6461 mL |
MenA-IN-2 Related Classifications
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