MK-2748
MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ < 0.115 nM), showing only slightly weaker activity against gt3a (1.212 nM), and maintaining high inhibitory activity against drug-resistant mutant strains such as gt1b R155K (IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM). MK-2748 can be used in the research of HCV infection.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1193902-95-2
- Fòrmula: C42H56N6O10S
- Peso molecular:836.99
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 1193902-95-2
-
Peso molecular 836.99
-
Fòrmula C42H56N6O10S
-
SMILES
O=C([C@H](C[C@](OC(N1CCCCC[C@@]2([H])[C@](CCC2)([H])O3)=NC4=CC(OC)=CC=C4C1=O)([H])C5)N5C([C@H](C6CCCC6)NC3=O)=O)N[C@]7([C@H](C=C)C7)C(NS(=O)(C8(CC8)C)=O)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK-2748 Related Classifications
HY-19932 Related Classifications
Powered by Bioz