ML2006a4
ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (Mpro) with IC50 in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level
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- No. CAS: 2943213-62-3
- Fòrmula: C30H44F3N5O6
- Peso molecular:627.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
ML2006a4 (40 mg/kg, p.o., twice a day for 4 days) ameliorates the SARS-CoV-2 infection, exhibits viral inhibitory and lung protective efficacy in BALB/c mice without significant toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SARS-CoV-2 MA10 infected BALB/c mice[1]
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Dosage:40 mg/kg
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Administration:p.o., twice a day for 4 days
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Result:Reduced inflammation and respioratory epithelial injury, improved epithelial regeneration and the survival rates with minimal weight loss.
Chemical Information
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No. CAS 2943213-62-3
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Peso molecular 627.70
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Fòrmula C30H44F3N5O6
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SMILES
O=C([C@@H]1[C@@]2([H])C(C)(C)[C@@]2([H])CN1C([C@@H](NC(C(F)(F)F)=O)C(C)(C)C)=O)N[C@H](C(C(N3CC(C)(C)C3)=O)=O)C[C@H]4C(NCCC4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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