Narsoplimab
Based on 1 publication(s) in Google Scholar
Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : ≥99.0%
- No. CAS: 2108782-45-0
- Peso molecular:143.1 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Narsoplimab
More
Actividad biológica
Descripciòn
Isotype
Human IgG4 lambda
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
MASP2
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT and Masp2-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)[1]
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Dosage:10 mg/kg
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Administration:Intravenous injection
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Result:Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 lambda
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized MASP2 Protein, Human (His) can bind Narsoplimab. The EC50 for this effect is 12.79 ng/mL.
Chemical Information
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No. CAS 2108782-45-0
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Appearance Liquid
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Peso molecular 143.1 kDa
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Color Colorless to light yellow
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SMILES
[Narsoplimab]
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Synonyms
OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Blood Adv
CG001, a C3b-targeted complement inhibitor blocks three complement pathways: development and preclinical evaluation. [Abstract]2024 Aug 13;8(15):4181-4193. PMID: 38865712
Pureza y Documentación
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Ficha de datos (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)