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Referencia número: HY-P11837

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NECT-224

NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with ⁶⁴Cu or ⁶⁸Ga.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₁₃H₁₅₃N₂₇O₃₃S₃
Peso molecular:2513.78

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Síntesis personalizada de péptidos

NECT-224 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with ⁶⁴Cu or ⁶⁸Ga^[1]^[2].

In Vitro

NECT-224 binds to recombinant human nectin-4 with a dissociation constant of 1.64 nM, demonstrating high target affinity^[1].
NECT-224 binds to the Ig-like V domain of nectin-4, forming the basis for radiotracers enabling tumor imaging^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 2513.78
Fòrmula C₁₁₃H₁₅₃N₂₇O₃₃S₃
Sequence

NODAGA-Cys-Pro-{1Nal}-{d-Asp}-Cys-{Mox}-{hArg}-Asp-Trp-Ser-Thr-Pro-{Hyp}-Trp-Cys-NH2 (TATA?covalent?with?Cys1,Cys5,Cys15)
Sequence Shortening

NODAGA-CP-{1Nal}-{d-Asp}-C-{Mox}-{hArg}-DWSTP-{Hyp}-WC-NH2 (TATA covalent with Cys1,Cys5,Cys15)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Krönke T, et al. "Precision on Two Wheels"─Structural Refinement of ⁶⁴Cu- and ⁶⁸Ga-Labeled Bicyclic Peptides Targeting Nectin-4 for Improved Tumor Imaging: From Preclinical Development to First-in-Human Application. J Med Chem. 2025;68(20):21962-21987. [Content Brief]

[2]. H Ou, et al. Cutting-edge advances in bicyclic peptide-based radiotracers for cancer imaging and theranostics. VIEW.2026, 7, 20250181.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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