NITD-688
Based on 1 Customer Validation
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.04%
- No. CAS: 2407227-31-8
- Fòrmula: C25H32N4O3S2
- Peso molecular:500.68
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
NS4B[1]
NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM[1].
NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM[1].
NITD-688 directly binds to wild-type but not mutant NS4B protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Infected AG129 mice[1]
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Dosage:30 mg/kg
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Administration:Oral gavage, twice daily for 3 days
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Result:Resulted in a 1.16-log reduction in viremia.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2407227-31-8
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Appearance Solid
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Peso molecular 500.68
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Fòrmula C25H32N4O3S2
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Color White to off-white
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SMILES
N#CC(C(CN1CC2CCCCC2)=C(CC(C)1C)S3)=C3NC(CC(C=C4)=CC=C4[S](N)(=O)=O)=O
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Synonyms
EYU-688
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (199.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9973 mL | 9.9864 mL | 19.9728 mL | 49.9321 mL |
| 5 mM | 0.3995 mL | 1.9973 mL | 3.9946 mL | 9.9864 mL | |
| 10 mM | 0.1997 mL | 0.9986 mL | 1.9973 mL | 4.9932 mL | |
| 15 mM | 0.1332 mL | 0.6658 mL | 1.3315 mL | 3.3288 mL | |
| 20 mM | 0.0999 mL | 0.4993 mL | 0.9986 mL | 2.4966 mL | |
| 25 mM | 0.0799 mL | 0.3995 mL | 0.7989 mL | 1.9973 mL | |
| 30 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL | 1.6644 mL | |
| 40 mM | 0.0499 mL | 0.2497 mL | 0.4993 mL | 1.2483 mL | |
| 50 mM | 0.0399 mL | 0.1997 mL | 0.3995 mL | 0.9986 mL | |
| 60 mM | 0.0333 mL | 0.1664 mL | 0.3329 mL | 0.8322 mL | |
| 80 mM | 0.0250 mL | 0.1248 mL | 0.2497 mL | 0.6242 mL | |
| 100 mM | 0.0200 mL | 0.0999 mL | 0.1997 mL | 0.4993 mL |
NITD-688 Related Classifications
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