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Referencia número: HY-168017

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NSC682769

NSC682769 is a PROTAC YAP-targeting ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016).

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No. CAS: 205048-79-9
Fòrmula: C₂₇H₂₂N₂O₃
Peso molecular:422.48

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

NSC682769 Chemical Structure

No. CAS: 205048-79-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

NSC682769 is a PROTAC YAP-targeting ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016)^[1].

Ver todos los productos específicos de isoformas YAP :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	IC₅₀	69 μM Compound: 6 : NSC682769	Antiproliferative activity against human Huh-7 cells overexpressing YAP assessed as cell growth inhibition incubated for 4 days by CCK-8 assay Antiproliferative activity against human Huh-7 cells overexpressing YAP assessed as cell growth inhibition incubated for 4 days by CCK-8 assay	[PMID: 39189384]
NCI-H226	IC₅₀	3.9 μM Compound: 6 : NSC682769	Antiproliferative activity against NF2 deficient- human NCI-H226 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay Antiproliferative activity against NF2 deficient- human NCI-H226 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay	[PMID: 39189384]

Chemical Information

No. CAS 205048-79-9
Peso molecular 422.48
Fòrmula C₂₇H₂₂N₂O₃
SMILES

O=C1NC2=CC=CC=C2C3=NC(C4=CC=CC=C4)=CC(C(C=C5OC)=CC=C5OC)=C3C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhou C, et al. Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras. J Med Chem. 2024 Sep 12;67(17):15168-15198. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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