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Referencia número: HY-129059

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Odapipam

(Synonyms: NNC 756)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D₁ receptor antagonist with a K_d of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer.

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Pureza: 99.00%
No. CAS: 131796-63-9
Fòrmula: C₁₉H₂₀ClNO₂
Peso molecular:329.82

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Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Odapipam Chemical Structure

No. CAS: 131796-63-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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IC₅₀ & Target

Dopamine D₁ receptor^[1]

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In Vivo

The metabolism of Odapipam has been studied with phenobarbital-induced rat liver microsomes. During the incubation of Odapipam, five different metabolites are formed. The electron-ionization (EI⁺) mass spectra of the metabolites indicated the formation of N-desmethyl-Odapipam, 1-hydroxy-Odapipam, the two isomers of 3′-hydroxy-Odapipam and a metabolite which is dehydrogenated in the dihydrobenzofuran moiety^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 131796-63-9
Appearance Solid
Peso molecular 329.82
Fòrmula C₁₉H₂₀ClNO₂
Color White to off-white
SMILES

OC1=C(Cl)C=C2CCN(C)C[C@H](C3=C(OCC4)C4=CC=C3)C2=C1
Synonyms

NNC 756
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Naunyn Schmiedebergs Arch Pharmacol

Contractile effects of stimulation of D1-dopamine receptors in the isolated human atrium. [Abstract]

2025 Feb;398(2):1497-1508. PMID: 39102031
bioRxiv

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection. [Abstract]

2026 Jan 6:2026.01.06.697936. PMID: 41542404

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (279 KB)
SDS (251 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
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Referencias

[1]. Abi-Dargham A, et al. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse. 1999 May;32(2):93-109. [Content Brief]

[2]. Nielsen EB, et al. Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists. Eur J Pharmacol. 1992 Aug 14;219(1):35-44. [Content Brief]

[3]. J. VANGGAARD ANDERSEN, et al. Normal-phase liquid chromatography-particle-beam mass spectrometry in drug metabolism studies of the dopamine receptor antagonist Odapipam and the muscarine M1 receptor agonist Xanomeline. Xenobiotica. 1997, 27: 901-912.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Odapipam

2 Cited Publications

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Odapipam

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Odapipam

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Publications Citing Use of MedChemExpress (MCE) Odapipam

Ver todos los productos específicos de isoformas Dopamine Receptor

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Odapipam Related Classifications

HY-129059 Related Classifications