OM99-2
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM. OM99-2 is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 314266-76-7
- Fòrmula: C41H64N8O14
- Peso molecular:892.99
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-16759A
Verubecestat TFABACE1/2 Inhibitor -
HY-10472
LY2811376BACE1 Inhibitor -
HY-13240A
LY2886721 hydrochlorideBACE1 Inhibitor -
HY-10133
β-Secretase Inhibitor IVBACE-1 Inhibitor -
HY-136742
BACE2-IN-1BACE2 Inhibitor -
HY-12938
AMG-8718BACE1 Inhibitor -
HY-100182
BACE1-IN-1BACE1/2 Inhibitor -
HY-100740C
(1α,1'S,4β)-LanabecestatLanabecestat Enantiomer -
HY-10472R
LY2811376 (Standard)Reference Standard -
HY-100182R
BACE1-IN-1 (Standard)Reference Standard -
HY-10133R
β-Secretase Inhibitor IV (Standard)BACE-1 Inhibitor -
HY-100740CR
(1α,1'S,4β)-Lanabecestat (Standard)Lanabecestat Enantiomer
Actividad biológica
Descripciòn
IC50 & Target
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BACE1 |
In Vitro
Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 314266-76-7
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Peso molecular 892.99
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Fòrmula C41H64N8O14
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Pureza y Documentación
Referencias
[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [Content Brief]
[2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [Content Brief]
[3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [Content Brief]
[4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OM99-2 Related Classifications
HY-P2713 Related Classifications
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