Phenanthridine
Phenanthridine is an aldehyde oxidase 1 (AOX1) substrate, with oxidation by hAOX1 yielding phenanthridone when molecular oxygen, ferricyanide, or dichlorophenolindophenol serves as electron acceptor.
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- No. CAS: 229-87-8
- Fòrmula: C13H9N
- Peso molecular:179.22
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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AOX1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
50 μM
Compound: 5b
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Cytotoxicity against human A549 cells incubated for 24 to 48 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 24 to 48 hrs by MTT assay
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[PMID: 40147342] |
Phenanthridine (40 μM) is used as substrate to show that in vitro chemical sulfuration increases the specific activity of hAOX1-WT, co-hAOX1, and hAOX1-S1271L by ~10-fold, with hAOX1-WT reaching 1516.7 mU/mg, co-hAOX1 reaching 1459.1 mU/mg, and hAOX1-S1271L reaching 1132.1 mU/mg after sulfuration[1].
Phenanthridine is used as substrate to show that codon-optimized hAOX1-WT has a pH optimum of ~8.0, while hAOX1-S1271L has a slightly shifted pH optimum of ~8.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 229-87-8
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Appearance Solid
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Peso molecular 179.22
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Fòrmula C13H9N
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Color White to off-white
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SMILES
N1=CC2=CC=CC=C2C3=CC=CC=C13
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phenanthridine Related Classifications
HY-W142745 Related Classifications
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