Propiolamide
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Propiolamide is a monooxygenase (MMO) system activator and glutathione peroxidase 4 (GPX4) inhibitor. Propiolamide induces ROS production through interaction with the MMO system. Propiolamide promotes the accumulation of intracellular cytotoxic lipid peroxides and induces ferroptosis. Propiolamide induces programmed cell death via the apoptosis pathway. Propiolamide can be used in cancer research.
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- No. CAS: 7341-96-0
- Fòrmula: C3H3NO
- Peso molecular:69.06
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Almacenamiento:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Actividad biológica
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GPX4 |
Propiolamide (14 mM; 0-30 min) induces microsomal monooxygenase-mediated reactive oxygen species production in CYP3A4/CPR/Cyt c and CYP3A4/NADPH systems[1].
Propiolamide (38 μM) inhibits the activity of glutathione peroxidase 4 derived from bovine red blood cells by 46%[1].
Propiolamide (30-50 μM; 12 h) induces apoptosis in HeLa cells in a concentration-dependent manner in vitro. After 12 hours of treatment, the proportion of total apoptotic cells reaches 7.13% at 30 μM and 10.33% at 50 μM[1].
Propiolamide (50 μM; 12 h) promotes lipid peroxidation in HeLa cells, which is a key marker of ferroptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa human cervical cancer cells
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Concentration:30 μM; 50 μM
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Incubation Time:12 h
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Result:Increased total apoptotic cells (early + late stage) from 4.30% (untreated control) to 7.13% at 30 μM.
Further increased total apoptotic cells to 10.33% at 50 μM.
Chemical Information
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No. CAS 7341-96-0
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Appearance Solid
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Peso molecular 69.06
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Fòrmula C3H3NO
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Color Off-white to light yellow
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SMILES
O=C(C#C)N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureza y Documentación
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Ficha de datos (270 KB)
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- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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