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Referencia número: HY-121605

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RL71

Revisión del cliente

Based on 1 Customer Validation

RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 97.44%
No. CAS: 1195795-93-7
Fòrmula: C₂₆H₃₁NO₇
Peso molecular:469.53

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

RL71 Chemical Structure

No. CAS: 1195795-93-7

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Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
A549	IC₅₀	1.7 μM Compound: 5B	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
K562	IC₅₀	0.9 μM Compound: B10	Inhibition of NF-kappaB activation in human K562 cells Inhibition of NF-kappaB activation in human K562 cells	[PMID: 20728364]
L02	IC₅₀	26.4 μM Compound: 5B	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
MDA-MB-231	EC₅₀	0.3 μM Compound: B10	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 20728364]
MDA-MB-231	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-468	EC₅₀	0.3 μM Compound: B10	Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay	[PMID: 20728364]
MDA-MB-468	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MG-63	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MV4-11	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H1650	IC₅₀	1.5 μM Compound: 5B	Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
NCI-H1975	IC₅₀	1 μM Compound: 5B	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
NCI-H23	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H460	IC₅₀	1 μM Compound: 5B	Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
SK-BR-3	IC₅₀	0.4 μM Compound: B10	Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay	[PMID: 20728364]

Chemical Information

No. CAS 1195795-93-7
Appearance Solid
Peso molecular 469.53
Fòrmula C₂₆H₃₁NO₇
Color Light yellow to yellow
SMILES

O=C1/C(CN(C/C1=C\C2=CC(OC)=C(C(OC)=C2)OC)C)=C/C3=CC(OC)=C(C(OC)=C3)OC
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (212.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1298 mL

10.6489 mL

21.2979 mL

5 mM

0.4260 mL

2.1298 mL

4.2596 mL

10 mM

0.2130 mL

1.0649 mL

2.1298 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yadav B, et al. RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells. Int J Oncol. 2012 Sep;41(3):1119-27. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1298 mL	10.6489 mL	21.2979 mL	53.2447 mL
	5 mM	0.4260 mL	2.1298 mL	4.2596 mL	10.6489 mL
	10 mM	0.2130 mL	1.0649 mL	2.1298 mL	5.3245 mL
	15 mM	0.1420 mL	0.7099 mL	1.4199 mL	3.5496 mL
	20 mM	0.1065 mL	0.5324 mL	1.0649 mL	2.6622 mL
	25 mM	0.0852 mL	0.4260 mL	0.8519 mL	2.1298 mL
	30 mM	0.0710 mL	0.3550 mL	0.7099 mL	1.7748 mL
	40 mM	0.0532 mL	0.2662 mL	0.5324 mL	1.3311 mL
	50 mM	0.0426 mL	0.2130 mL	0.4260 mL	1.0649 mL
	60 mM	0.0355 mL	0.1775 mL	0.3550 mL	0.8874 mL
	80 mM	0.0266 mL	0.1331 mL	0.2662 mL	0.6656 mL
	100 mM	0.0213 mL	0.1065 mL	0.2130 mL	0.5324 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias

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RL71

Cysteine Targeted Covalent Library

Cell Death Library

Bioactive Compound Library Max

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

RL71

Cysteine Targeted Covalent Library

Cell Death Library

Bioactive Compound Library Max

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

RL71 Related Classifications

HY-121605 Related Classifications