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Referencia número: HY-103216

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RWJ52353

RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with K_is of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED₅₀ of 15.1 mg/kg.

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No. CAS: 245744-10-9
Fòrmula: C₁₁H₁₀N₂S
Peso molecular:202.28

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

RWJ52353 Chemical Structure

No. CAS: 245744-10-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target

Alpha-2D adrenergic receptor

1.5 nM (Ki)

Alpha-2A adrenergic receptor

254 nM (Ki)

α1-adrenergic receptor

443 nM (Ki)

Alpha-2B adrenergic receptor

621 nM (Ki)

Ver todos los productos específicos de isoformas Adrenergic Receptor :

Chemical Information

No. CAS 245744-10-9
Peso molecular 202.28
Fòrmula C₁₁H₁₀N₂S
SMILES

C1(C2=CCCC3=C2C=CS3)=CN=CN1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Ross TM, et al., alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor. J Med Chem. 2000 Mar 9;43(5):765-8. [Content Brief]

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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RWJ52353

Ver todos los productos específicos de isoformas Adrenergic Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

RWJ52353 Related Classifications

HY-103216 Related Classifications