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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
81 Results for "
Li diffusion
" in MedChemExpress (MCE) Product Catalog:
Products (81)
81 Results for "Li diffusion" in MCE Product Catalog:
45
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Áreas de investigación:
Acridine Orange hydrochloride is a cell-permeable fluorescent nucleic acid dye and lysosomal probe with a pKa of 9.65. Acridine Orange hydrochloride enters cells via passive diffusion, is protonated and accumulates in acidic lysosomes, and forms aggregates at high concentrations, producing orange-red fluorescence; when the lysosomal proton gradient or membrane integrity is impaired, Acridine Orange hydrochloride is released into the cytoplasm, green fluorescence increases and red fluorescence decreases, so it can be used to monitor lysosomal acidification status and changes in membrane permeability. Acridine Orange hydrochloride binds to nucleic acids through intercalation or electrostatic interactions, exhibiting mainly green fluorescence when bound to double-stranded DNA and mainly red fluorescence when bound to RNA or single-stranded DNA, and can be used for nucleic acid staining and differential DNA/RNA detection. The Ex/Em of Acridine Orange hydrochloride monomer is approximately 492/525 nm; when bound to double-stranded DNA it is approximately 488/520-524 nm, and when bound to RNA or single-stranded DNA it is approximately 457/630-650 nm .
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Acridine Orange base is a cell-permeable fluorescent nucleic acid dye and lysosomal probe with a pKa of 9.65. Acridine Orange base enters cells via passive diffusion, is protonated and accumulates in acidic lysosomes, and forms aggregates at high concentrations, producing orange-red fluorescence; when the lysosomal proton gradient or membrane integrity is impaired, Acridine Orange base is released into the cytoplasm, green fluorescence increases and red fluorescence decreases, so it can be used to monitor lysosomal acidification status and changes in membrane permeability. Acridine Orange base binds to nucleic acids through intercalation or electrostatic interactions, exhibiting mainly green fluorescence when bound to double-stranded DNA and mainly red fluorescence when bound to RNA or single-stranded DNA, and can be used for nucleic acid staining and differential DNA/RNA detection. The Ex/Em of Acridine Orange base monomer is approximately 492/525 nm; when bound to double-stranded DNA it is approximately 488/520-524 nm, and when bound to RNA or single-stranded DNA it is approximately 457/630-650 nm .
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45 Publications Verification
Referencia número: HY-D0942
No. CAS: 10127-02-3
Synonyms: Euchrysine 3RX
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Áreas de investigación:
Acridine Orange zinc chloride salt is a cell-permeable fluorescent nucleic acid dye and lysosomal probe with a pKa of 9.65. Acridine Orange zinc chloride salt enters cells via passive diffusion, is protonated and accumulates in acidic lysosomes, and forms aggregates at high concentrations, producing orange-red fluorescence; when the lysosomal proton gradient or membrane integrity is impaired, Acridine Orange zinc chloride salt is released into the cytoplasm, green fluorescence increases and red fluorescence decreases, so it can be used to monitor lysosomal acidification status and changes in membrane permeability. Acridine Orange zinc chloride salt binds to nucleic acids through intercalation or electrostatic interactions, exhibiting mainly green fluorescence when bound to double-stranded DNA and mainly red fluorescence when bound to RNA or single-stranded DNA, and can be used for nucleic acid staining and differential DNA/RNA detection. The Ex/Em of Acridine Orange zinc chloride salt monomer is approximately 492/525 nm; when bound to double-stranded DNA it is approximately 488/520-524 nm, and when bound to RNA or single-stranded DNA it is approximately 457/630-650 nm .
7
Áreas de investigación:
Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer .
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6 Cited Publications
Referencia número: HY-D0722
No. CAS: 124387-19-5
Synonyms: 5-(6)-Carboxyfluorescein diacetate; CFDA
3
3 Cited Publications
Referencia número: HY-D0047
No. CAS: 79955-27-4
Synonyms: 5-Carboxyfluorescein diacetate
1
Áreas de investigación:
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) targeting HER3, consisting of the anti-HER3 IgG1 antibody Patritumab (HY-P99275), a cleavable tetrapeptide linker, and the membrane-permeable topoisomerase I (Topoisomerase Ⅰ) inhibitor DXd (HY-13631D). After binding to membrane-localized HER3, Patritumab deruxtecan is internalized into lysosomes, where the linker is cleaved to release DXd. DXd enters the nucleus to induce DNA damage and cell death, and exerts a bystander effect via transmembrane diffusion. Patritumab deruxtecan reduces the viability of HER3-positive cells and induces features of immunogenic cell death including CALR membrane exposure, ATP and HMGB1 release, and can be used in studies related to HER3-positive breast cancer and non-small cell lung cancer .
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1
1 Cited Publications
Referencia número: HY-112624I
No. CAS: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
Referencia número: HY-W012382
No. CAS: 537-55-3
Category:
Human Gut Microbiota Metabolites Monophenols Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Phenols Endogenous metabolite Disease Research Fields
Target:
Referencia número: HY-B0396
No. CAS: 161715-24-8
Synonyms: L084
Áreas de investigación:
Tebipenem pivoxil (L084) is an orally active carbapenem Antibiotic. Tebipenem pivoxil acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil can bind to penicillin-binding proteins (PBPs), thereby inhibiting cell wall synthesis. Tebipenem pivoxil can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
Referencia número: HY-W007432
No. CAS: 787618-22-8
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Acetylcholinesterase, Electric eel is a cholinergic enzyme that is mainly found in neuromuscular junctions and cholinergic chemical synapses and is often used in biochemical research. Acetylcholinesterase, Electric eel can catalyze the decomposition or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetic acid and choline. The main function of Acetylcholinesterase, Electric eel is to terminate neuronal transmission and signal conduction between synapses to prevent ACh diffusion and activation of nearby receptors .
Synonyms: Hypromellose (Type I,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:100mPa.s); Celacol HPM 5000 (Type I,Viscosity:100mPa.s)
Synonyms: Hypromellose (Type II,Viscosity:3mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:3mPa.s); Celacol HPM 5000 (Type II,Viscosity:3mPa.s)
Áreas de investigación:
HPMC (Type II, Viscosity: 3 mPa.s) is a nonionic polymer prepared via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, which includes the diffusion of drugs in the hydrated matrix and the polymer relaxation process .
Synonyms: Hypromellose (Type II,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100mPa.s); Celacol HPM 5000 (Type II,Viscosity:100mPa.s)
Synonyms: Hypromellose (Type II,Viscosity:100000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100000mPa.s); Celacol HPM 5000 (Type II,Viscosity:100000mPa.s)
Referencia número: HY-D0805
No. CAS: 60520-47-0
Referencia número: HY-W010514
No. CAS: 1460-57-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
