SIMR3030
SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice.
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- No. CAS: 2708270-99-7
- Fòrmula: C27H29N3O2
- Peso molecular:427.54
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 0.0399 µg/mL (SARS-CoV-2 PLpro)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
55.63 μg/mL
Compound: SIMR3030
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Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by crystal violet staining based analysis
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[PMID: 37075625] |
In Vitro
SIMR3030 (0-100 µg/mL) shows antiviral activity with IC50 values of 12.1, 6.206 μg/mL for SARS-CoV-2 and MERS-CoV, respectively[1].
SIMR3030 (20 µg/mL; 1, 6, 12 h) decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression levels in Caco-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2 cells (SARS-CoV-2 RNA infected)
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Concentration:20 μg/mL
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Incubation Time:1, 6, 12 h
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Result:Decreased SARS-CoV spike and ORF1b mRNA expression levels, reduced the mRNA expression of IFN-α at 1 and 3 h , IL-6 and OAS1 at 1, 3 and 12 h.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:18-25 g, adult female Balb/c mice[1]
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Dosage:25, 50, 100 mg/kg
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Administration:I.p.; daily for 14 days
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Result:Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.
Chemical Information
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No. CAS 2708270-99-7
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Peso molecular 427.54
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Fòrmula C27H29N3O2
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SMILES
[H][C@@]12CC[C@]3(CC4=C(NC5=C4C=C(C=C5)OC)C[C@]3(N1CCC6=C2NC7=CC=CC=C76)[H])OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIMR3030 Related Classifications
HY-149940 Related Classifications
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