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Referencia número: HY-P992510

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Biologically Validated

Sofetabart

Name: Sofetabart
Brand: MedChemExpress
SKU: HY-P992510
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: LY-4170156 Antibody; MBK-103 Antibody)

Revisión del cliente

Based on 1 Customer Validation

Sofetabart (LY-4170156 Antibody) is a humanized IgG1 antibody that specifically targets folate receptor α (FRα). Sofetabart can be used to synthesize the antibody-drug conjugate (ADC) Sofetabart mipitecan. Sofetabart is applicable to research related to advanced ovarian cancer, platinum-resistant epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer, as well as platinum-sensitive ovarian cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza : 98.00%
No. CAS: 3066905-22-1
Peso molecular:145.23 kDa

Almacenamiento:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Sofetabart Chemical Structure

No. CAS: 3066905-22-1

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Aplicación
- Verified Bioactivity
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]^[2]^[3]^[4]

FR-α

Ver todos los productos específicos de isoformas Folate Receptor (FR) :

FR-α

In Vitro

Sofetabart (LY-4170156 Antibody) serves as an FRα-targeting antibody for synthesizing the sofetabart mipitecan antibody-drug conjugate (ADC)^[1]^[2]^[3]^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

2348 [NCBI]

Accession

P15328

Target

FOLR1/FRA

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Aplicación

ELISA, FACS, Functional assay

Verified Bioactivity

Loaded Sofetabart on ProA biosensor, can bind FOLR1 Protein, Human (HEK293, HY-P70296) with an affinity constant of 2.087E-08 M as determined in BLI assay.

Chemical Information

No. CAS 3066905-22-1
Peso molecular 145.23 kDa
Synonyms

LY-4170156 Antibody; MBK-103 Antibody
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (260 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. O'Malley D, et al. Update from the phase I study of sofetabart mipitecan (Sofe-M), an antibody-drug conjugate (ADC) targeting folate receptor alpha (FRα) in advanced ovarian cancer (OC) [abstract]. ESMO Open. 2026;11(Suppl 6):108188.

[2]. Coyle L. Industry Insights: Bioconjugate innovation gains momentum across partnerships and pivotal trials. Bioconjugate Insights. 2026;1(1):49‑66.

[3]. Moore KN, et al. Antibody-drug conjugates in gynaecological cancers: opportunities and challenges. Nature reviews. Clinical oncology. 2026 Jun 17. [Content Brief]

[4]. Ray‑Coquard IL, et al. FRAmework‑01: A two‑part phase 3 study of sofetabart mipitecan versus chemotherapy or mirvetuximab soravtansine in platinum‑resistant ovarian cancer (PROC), and sofetabart mipitecan plus bevacizumab versus platinum‑based chemotherapy plus bevacizumab in platinum‑sensitive ovarian cancer (PSOC). J Clin Oncol. 2026;44(16_suppl):TPS5644.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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