Spinacine
Based on 1 Customer Validation
Spinacine ((S)-Spinacine) is a GABA uptake inhibitor. Spinacine enhances synaptic GABA effects via inhibition of gamma-aminobutyric acid uptake in cerebral cortex slices. Spinacine inhibits reflex responses of ventral roots in isolated spinal cord. Spinacine inhibits motor activity and reduces approaches to water dispensers in conflict situations. Spinacine raises pain sensitivity threshold via subarachnoidal injection.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.96%
- No. CAS: 59981-63-4
- Fòrmula: C7H9N3O2
- Peso molecular:167.17
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Actividad biológica
Spinacine (3 mg/kg; subarachnoidal; single dose) increases rats' pain sensitivity threshold by 1.5-2-fold for 1 hour[1].
Spinacine (100 mg/kg; i.p.; single dose) has no detectable effect on white mice motor activity, orientative behavior, corazole-induced convulsions, or muscle tone[1].
Spinacine (100 mg/kg; i.p.; single dose) does not exhibit analgesic activity in mice tested via mechanical tail compression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Normal rat[1]
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Dosage:10 mg/kg
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Administration:i.p.; single dose
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Result:Reduced mean horizontal movements to 35.7 ± 19.4 over 20 minutes.
Reduced mean approaches to water dispenser to 10.3 ± 4.4 over 20 minutes.
Left mean water takings unchanged at 6.8 ± 1.72 over 20 minutes.
Produced statistically significant changes in approaches and horizontal movement compared to controls.
Chemical Information
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No. CAS 59981-63-4
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Appearance Solid
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Peso molecular 167.17
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Fòrmula C7H9N3O2
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Color White to off-white
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SMILES
O=C([C@@H]1CC2=C(NC=N2)CN1)O
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Synonyms
(S)-Spinacine
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
H2O : 33.33 mg/mL (199.38 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 4.55 mg/mL (27.22 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
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- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.9819 mL | 29.9097 mL | 59.8193 mL | 149.5484 mL |
| 5 mM | 1.1964 mL | 5.9819 mL | 11.9639 mL | 29.9097 mL | |
| 10 mM | 0.5982 mL | 2.9910 mL | 5.9819 mL | 14.9548 mL | |
| 15 mM | 0.3988 mL | 1.9940 mL | 3.9880 mL | 9.9699 mL | |
| 20 mM | 0.2991 mL | 1.4955 mL | 2.9910 mL | 7.4774 mL | |
| 25 mM | 0.2393 mL | 1.1964 mL | 2.3928 mL | 5.9819 mL | |
| 30 mM | 0.1994 mL | 0.9970 mL | 1.9940 mL | 4.9849 mL | |
| 40 mM | 0.1495 mL | 0.7477 mL | 1.4955 mL | 3.7387 mL | |
| 50 mM | 0.1196 mL | 0.5982 mL | 1.1964 mL | 2.9910 mL | |
| 60 mM | 0.0997 mL | 0.4985 mL | 0.9970 mL | 2.4925 mL | |
| 80 mM | 0.0748 mL | 0.3739 mL | 0.7477 mL | 1.8694 mL | |
| 100 mM | 0.0598 mL | 0.2991 mL | 0.5982 mL | 1.4955 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Spinacine Related Classifications
HY-W067716 Related Classifications
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