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Referencia número: HY-P991030

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Biologically Validated

Tabirafusp alfa

(Synonyms: OG-2072)

Revisión del cliente

Based on 1 Customer Validation

Tabirafusp alfa (OG-2072, KSI-101) is a bispecific antibody trap fusion protein that inhibits IL-6 and VEGF. Tabirafusp alfa is a first-in-class, high-strength intravitreal biologic designed to target IL-6 mediated inflammation and VEGF-mediated vascular permeability in macular edema secondary to inflammation (MESI).

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.08%
No. CAS: 2839527-15-8

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tabirafusp alfa Chemical Structure

No. CAS: 2839527-15-8

Tamaño

Precio

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Cantidad

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Verified Bioactivity
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-6^[1]

Ver todos los productos específicos de isoformas Interleukin Related :

In Vivo

Tabirafusp alfa (KSI-101) (10 mg/ocular/dose) administered via intravitreal injection (IVT) three times every 4 weeks was well-tolerated in cynomolgus monkeys, with no observed changes in body weight or effects on pathological or organ weight parameters^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

3569 [NCBI]

Accession

P05231

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-kappa-[2PROTEINS]2-in-VH_1cys_drug

Aplicación

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-6 Protein, Human (HY-P7044) can bind Tabirafusp alfa. The EC₅₀ for this effect is 51.98 ng/mL.

Chemical Information

No. CAS 2839527-15-8
Appearance Liquid
Color Colorless to light yellow
SMILES

[Tabirafusp alfa]
Synonyms

OG-2072
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Yih-Shiou Hwang, et al. Bispecific trap-antibody inhibiting Interleukin-6 and Vascular Endothelial Growth Factor (KSI-101): Clinical PK/PD cohort in Asian patients with macular edema secondary to inflammation (MESI). ARVO Annual Meeting Abstract. June 2026.

[2]. John Sinclair, et al. Ocular Toxicity Study of KSI-101 Demonstrates Tolerability after Intravitreal Administration in Cynomolgus Monkeys. ARVO Annual Meeting Abstract. June 2025.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Biological Activity
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Tabirafusp alfa

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Antibody Inhibitor Library

Ver todos los productos específicos de isoformas Interleukin Related

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Tabirafusp alfa Related Classifications

HY-P991030 Related Classifications