TG 41
TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes.
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- No. CAS: 850339-33-2
- Fòrmula: C18H13BrCl2N2O2
- Peso molecular:440.12
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
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| Oocyte | EC50 |
0.19 μM
Compound: 1n
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Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes
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[PMID: 15801854] |
TG41 (0.001-10 µM) increases specific [3H]GABA binding to rat cerebral cortical membranes[1].
TG41 (0.001-10 µM) increases inward Cl- currents in X. laevis oocytes expressing recombinant α1β2γ2L GABAA receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:5 mg/kg
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Administration:i.v.
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Result:Induced loss of the righting reflex within 8 s and for a duration of 28 min.
Chemical Information
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No. CAS 850339-33-2
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Peso molecular 440.12
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Fòrmula C18H13BrCl2N2O2
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SMILES
O=C(C1=CN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Br)C=C3)=N1)OCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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