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Referencia número: HY-177432

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TMX-4140

TMX-4140 is a selective PIP4K2C ligand with a K_d of 7.2 nM. TMX-4140 can be used to synthesize the PROTAC degrader TMX-4153 (HY-153119).

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No. CAS: 2867519-51-3
Fòrmula: C₂₅H₂₀ClN₅O
Peso molecular:441.91

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TMX-4140 Chemical Structure

No. CAS: 2867519-51-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

TMX-4140 is a selective PIP4K2C ligand with a K_d of 7.2 nM. TMX-4140 can be used to synthesize the PROTAC degrader TMX-4153 (HY-153119)^[1].

IC₅₀ & Target

^[1]

PIP4K2C

7.2 nM (Kd)

Ver todos los productos específicos de isoformas PI5P4K :

PI5P4Kγ

In Vitro

TMX-4140 binds PIP4K2C with K_D = 7.2 nM while sparing PIP4K2B (K_D >10000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2867519-51-3
Peso molecular 441.91
Fòrmula C₂₅H₂₀ClN₅O
SMILES

ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N5CCCC5=O)=CN=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angewandte Chemie (International ed. in English). 2023 Apr 24;62(18):e202302364. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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TMX-4140

Ver todos los productos específicos de isoformas PI5P4K

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Chemical Information

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Referencias

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TMX-4140 Related Classifications

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