WS5
Based on 1 Customer Validation
WS5 (Menthane carboxamidoethyl acetate) is a cooling agent fragrance ingredient.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.93%
- No. CAS: 68489-14-5
- Fòrmula: C15H27NO3
- Peso molecular:269.38
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
WS5 (Up to 5000 μg/plate) is not mutagenic in the Ames test using Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and Escherichia coli strain WP2uvrA[1].
WS5 (1008.75 μg/mL; 4-24 h) is not mutagenic to MLA cells[1].
WS5 (Up to 2000 μg/mL) is non-clastogenic in the micronucleus test using human peripheral blood lymphocytes[1].
WS5 does not react with skin peptides in the in vitro direct peptide reactivity assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Crl:CD(SD) (male and female)[1]
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Dosage:25; 75; 225; 675 mg/kg
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Administration:p.o.; daily; 91 days
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Result:Showed no mortality across all doses.
Showed no treatment-related effects on body weights, food consumption, body temperature, or ophthalmic findings at any dose.
Reduced hematocrit values in males at 225 mg/kg/day, with no other treatment-related adverse effects.
Induced statistically significant increases in neutrophils, monocytes, and white blood cells in both sexes at 675 mg/kg/day.
Reduced hematocrit, hemoglobin, red blood cell counts, and mean corpuscular volume, plus increased red blood cell distribution width in both sexes at 675 mg/kg.
Increased serum creatinine, urea nitrogen, calcium, and triglyceride levels, plus total urine volume in both sexes at 675 mg/kg/day.
Decreased serum albumin/globulin ratios, chloride levels, and urine specific gravity in both sexes at 675 mg/kg.
Caused enlarged rough-surfaced kidneys in 1/10 males and pale kidneys in 1/10 females, plus increased kidney and liver weights at 675 mg/kg.
Induced kidney tubular degeneration, regeneration, dilatation, hyaline droplets, interstitial fibrosis, and tubular epithelium vacuolation in both sexes at 675 mg/kg/day.
Induced periportal hepatocellular vacuolation and centrilobular hepatocellular hypertrophy in both sexes at 675 mg/kg/day.
Induced cardiomyopathy in females at 675 mg/kg.
Showed slightly higher mean severity scores of α-2u-globulin nephropathy staining in male treatment groups, a species- and sex-specific effect not relevant to human health.
Chemical Information
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No. CAS 68489-14-5
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Appearance Solid
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Peso molecular 269.38
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Fòrmula C15H27NO3
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Color White to off-white
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SMILES
CCOC(CNC([C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)=O
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Synonyms
Menthane carboxamidoethyl acetate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (371.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7122 mL | 18.5611 mL | 37.1223 mL | 92.8057 mL |
| 5 mM | 0.7424 mL | 3.7122 mL | 7.4245 mL | 18.5611 mL | |
| 10 mM | 0.3712 mL | 1.8561 mL | 3.7122 mL | 9.2806 mL | |
| 15 mM | 0.2475 mL | 1.2374 mL | 2.4748 mL | 6.1870 mL | |
| 20 mM | 0.1856 mL | 0.9281 mL | 1.8561 mL | 4.6403 mL | |
| 25 mM | 0.1485 mL | 0.7424 mL | 1.4849 mL | 3.7122 mL | |
| 30 mM | 0.1237 mL | 0.6187 mL | 1.2374 mL | 3.0935 mL | |
| 40 mM | 0.0928 mL | 0.4640 mL | 0.9281 mL | 2.3201 mL | |
| 50 mM | 0.0742 mL | 0.3712 mL | 0.7424 mL | 1.8561 mL | |
| 60 mM | 0.0619 mL | 0.3094 mL | 0.6187 mL | 1.5468 mL | |
| 80 mM | 0.0464 mL | 0.2320 mL | 0.4640 mL | 1.1601 mL | |
| 100 mM | 0.0371 mL | 0.1856 mL | 0.3712 mL | 0.9281 mL |
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