OST4 - oligosaccharyltransferase complex subunit 4, non-catalytic Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 100128731

About OST4

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,070,472-27,071,654 (from NCBI)

This gene has 3 transcripts (splice variants) and 145 orthologues. Ubiquitous expression in colon (RPKM 112.3), adrenal (RPKM 106.4) and 25 other tissues.

Summary

Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

OST4 Products (1)

mRNA Protein Name
NM_001134693.2 NP_001128165.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
31831667 GOA
involved in protein N-linked glycosylation via asparagine IMP
IMP: Inferred from mutant phenotype
23606741 GOA
Cellular Component GO Annotation Evidence References Source
part of oligosaccharyltransferase complex IDA
IDA: Inferred from direct assay
23606741 GOA
part of oligosaccharyltransferase complex IPI
IPI: Inferred from physical interaction
31831667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OST4 Protein Structure

Ost4

Ost4: Oligosaccaryltransferase (1 - 35)

  • 0
  • 37 a.a.
Protein Preferred Names Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

  • oligosaccharyltransferase 4 homolog

OST4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OST4 P0C6T2 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bolivian Hemorrhagic Fever

  • Machupo Hemorrhagic Fever

  • Hemorrhagic Fever, Bolivian

  • Bhf - [Bolivian Haemorrhagic Fever]

  • Machupo Haemorrhagic Fever
Autosomal Recessive Intellectual Developmental Disorder

  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70172 Heparan Sulfate 3-O-Sulfotransferase 4 Modulator / Unkown
HY-RS09854 OST4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19625 Ost4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26121 Ost4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OST4 MGD MGI:1914945
Macaca mulatta OST4 VGNC VGNC:106191
Rattus norvegicus OST4 RGD RGD:2300150