NME6 - NME/NM23 nucleoside diphosphate kinase 6 Gene

Also Known as NDK 6; NM23-H6; IPIA-ALPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10201

About NME6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,288,402-48,301,367 (from NCBI)

This gene has 22 transcripts (splice variants), 182 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 3.8), ovary (RPKM 2.8) and 25 other tissues.

Summary

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous Enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

NME6 Products (9)

mRNA Protein Name
NM_001308426.2 NP_001295355.1 nucleoside diphosphate kinase 6 isoform 2
NM_001308427.2 NP_001295356.1 nucleoside diphosphate kinase 6 isoform 2
NM_001308428.2 NP_001295357.1 nucleoside diphosphate kinase 6 isoform 2
NM_001308430.2 NP_001295359.1 nucleoside diphosphate kinase 6 isoform 3
NM_001308431.2 NP_001295360.1 nucleoside diphosphate kinase 6 isoform 4
NM_001308433.2 NP_001295362.1 nucleoside diphosphate kinase 6 isoform 4
NM_001308434.2 NP_001295363.1 nucleoside diphosphate kinase 6 isoform 5
NM_001308435.2 NP_001295364.1 nucleoside diphosphate kinase 6 isoform 6
NM_005793.5 NP_005784.1 nucleoside diphosphate kinase 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nucleoside diphosphate kinase activity IDA
IDA: Inferred from direct assay
10618642 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
10618642 GOA
involved in negative regulation of mitotic nuclear division IDA
IDA: Inferred from direct assay
10618642 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
34789336 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
34789336 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
10618642 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NME6 Protein Structure

NDK

NDK: Nucleoside diphosphate kinase (13 - 147)

  • 0
  • 100
  • 186 a.a.
Protein Preferred Names Protein Names

nucleoside diphosphate kinase 6

  • NDP kinase 6

NME6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NME6 O75414 RCC1L Homo sapiens Q96I51
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymph Node Carcinoma

  • Lymph Node Cancer

  • Lymph Node Neoplasm

  • Neoplasm Of Lymph Node
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09377 NME6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NME6 VGNC VGNC:32128
Felis catus NME6 VGNC VGNC:63836
Macaca mulatta NME6 VGNC VGNC:75222
Canis familiaris NME6 VGNC VGNC:43857
Rattus norvegicus NME6 RGD RGD:61896
Mus musculus NME6 MGD MGI:1861676
Others NME6 NCBI