SMO - smoothened, frizzled class receptor Gene

Macaca fascicularis

Gene ID: 102121742 | Gene type: protein coding

About SMO

Primary_assembly 3: 156,506,210-156,530,838 forward strand.Macaca_fascicularis_6.0:CM021941.1

This gene has 4 transcripts (splice variants), 204 orthologues and 10 paralogues.

SMO Products(4)

mRNA	Protein	Name
XM_045388388.1	XP_045244323.1	smoothened homolog isoform X4
XM_005550738.3	XP_005550795.1	smoothened homolog isoform X1
XM_005550739.3	XP_005550796.1	smoothened homolog isoform X2
XM_045388387.1	XP_045244322.1	smoothened homolog isoform X3

SMO Protein Structure

CRD_SMO

7tmF_SMO_homolog

0
200
400
600
809 a.a.

Protein Preferred Names

Protein Names

smoothened homolog

smoothened, frizzled family receptor

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16582A	Sonidegib	Antagonist	99.98%	Yes
HY-16391	Glasdegib	Inhibitor	99.65%	Yes
HY-B0603	Fluticasone	Agonist	98.70%	Yes
HY-16582	Sonidegib diphosphate	Antagonist	99.97%	Yes
HY-B0877	Halcinonide	Agonist	98.29%	Unkown
HY-16391A	Glasdegib maleate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13654	IPI-269609	Inhibitor	/	Phase 4
HY-16587	Saridegib	Inhibitor	99.95%	Phase 3
HY-13809	BMS-833923	Inhibitor	99.82%	Phase 2
HY-13242	Taladegib	Inhibitor	99.92%	Phase 2
HY-18636	LEQ506	Inhibitor	98.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12848	SAG	Agonist	99.79%	Unkown
HY-17024	Cyclopamine	Inhibitor	99.97%	Unkown
HY-15108	Purmorphamine	Activator	99.9%	Unkown
HY-100224	SANT-1	Antagonist	99.87%	Unkown
HY-12848B	SAG hydrochloride	Agonist	99.91%	Unkown
HY-12848C	SAG dihydrochloride	Agonist	98.23%	Unkown
HY-15483	DY131	Inhibitor	99.72%	Unkown
HY-100535	KAAD-Cyclopamine	Antagonist	≥96.0%	Unkown
HY-12316	20(S)-Hydroxycholesterol	Activator	99.63%	Unkown
HY-12317	GSA-10	Agonist	≥98.0%	Unkown
HY-15108G	Purmorphamine (GMP)	Agonist	/	Unkown
HY-N0836	Jervine	Inhibitor	99.28%	Unkown
HY-13459	PF-5274857	Antagonist	99.31%	Unkown
HY-15412	HhAntag		99.40%	Unkown
HY-N0247	Saikosaponin B1	Inhibitor	99.42%	Unkown
HY-151115	JNJ-1289	Inhibitor	98.06%	Unkown
HY-12848R	SAG (Standard)	Agonist	99.56%	Unkown
HY-113965	CUR61414	Inhibitor	99.04%	Unkown
HY-137115	BODIPY-Cyclopamine		98.91%	Unkown
HY-100036	MK-4101	Antagonist	99.16%	Unkown
HY-117407	ALLO-2	Antagonist	99.72%	Unkown
HY-115566	S1PL-IN-1	Antagonist	99.9%	Unkown
HY-18287	MRT-83	Antagonist	99.27%	Unkown
HY-18287A	MRT-83 hydrochloride	Antagonist	99.60%	Unkown
HY-120499	AZD8542	Antagonist	99.49%	Unkown
HY-110240	IHR-1	Antagonist	98.05%	Unkown
HY-145387	MRT-81	Antagonist	99.85%	Unkown
HY-108507	MRT-10	Antagonist	98.99%	Unkown
HY-108508	SMANT hydrochloride	Inhibitor	99.90%	Unkown
HY-12316R	20(S)-Hydroxycholesterol (Standard)	Activator	98.69%	Unkown
HY-13459A	PF-5274857 hydrochloride	Antagonist	/	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-12848S	SAG-d3	Inhibitor	99.85%	Unkown
HY-150567	SMO-IN-3	Inhibitor	/	Unkown
HY-100224G	SANT-1 (GMP)	Antagonist	/	Unkown
HY-16391S1	Glasdegib-d4	Inhibitor	/	Unkown
HY-177291	LAB687	Antagonist	/	Unkown
HY-183335	SMO-IN-6	Inhibitor	/	Unkown
HY-148440	RL-0070933	Modulator	/	Unkown
HY-162372	Hedgehog IN-6	Inhibitor	/	Unkown
HY-162273	Antibacterial agent 189		/	Unkown
HY-12848A	(Rac)-SAG	Agonist	/	Unkown
HY-16391B	Glasdegib hydrochloride	Inhibitor	/	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-159893	SMO-IN-5	Inhibitor	/	Unkown
HY-147670	TPB15	Inhibitor	/	Unkown
HY-110326	Smo antagonist M25	Antagonist	/	Unkown
HY-131016	IHR-Cy3	Antagonist	/	Unkown
HY-145918	MRT-14	Antagonist	98.91%	Unkown
HY-153499	SMO-IN-4	Antagonist	/	Unkown
HY-123752	MS-0022	Antagonist	/	Unkown
HY-16587A	Saridegib hydrochloride	Inhibitor	/	Unkown
HY-150564	SMO-IN-2	Inhibitor	98.12%	Unkown
HY-117903A	MRT-92	Antagonist	/	Unkown
HY-133974	7-keto-25-Hydroxycholesterol	Activator	/	Unkown
HY-12848G	SAG (GMP)	Agonist	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990418	Anti-FZD7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	SMO	NCBI	NCBI:6608
Mus musculus	SMO	NCBI	NCBI:319757
Rattus norvegicus	SMO	NCBI	NCBI:25273

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