GPA33 - glycoprotein A33 Gene

Homo sapiens

Also known as A33

Gene ID: 10223 | Gene type: protein coding

About GPA33

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:167,052,836-167,090,377 (from NCBI)

This gene has 4 transcripts (splice variants), 232 orthologues and 14 paralogues. Biased expression in colon (RPKM 108.1), duodenum (RPKM 69.2) and 2 other tissues.

Summary

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

GPA33 Products(1)

mRNA	Protein	Name
NM_005814.3	NP_005805.1	cell surface A33 antigen precursor

GPA33 Protein Structure

V-set

Ig_2

0
100
200
300
319 a.a.

Protein Preferred Names

Protein Names

cell surface A33 antigen

glycoprotein A33 (transmembrane)

Recombinant GPA33 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70899	GPA33 Protein, Human (214a.a, HEK293, His)	Q99795 (I22-V235)	≥95%
HY-P74117	GPA33 Protein, Human (235a.a, HEK293, His)	Q99795 (M1-V235)	≥95%
HY-P78136	GPA33 Protein, Human (Biotinylated, HEK293, His-Avi)	Q99795 (I22-V235)	≥95%
HY-P78450	GPA33 Protein, Human (HEK293, His-Avi)	Q99795 (I22-V235)	≥95%
HY-P78867	GPA33 Protein, Human (Biotinylated, HEK293, His)	AAH74830 (I22-V235)	≥95%

Related Diseases

Diseases

Alias

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

Intestinal Botulism

Intestinal Colonization Botulism	Intestinal Toxemia Botulism
Intestinal Toxin-Mediated Botulism

Infant Botulism

Infant Intestinal Botulism	Infant Intestinal Toxemia Botulism
Infant Intestinal Toxin-Mediated Botulism	Infantile Botulism
Botulism, Infantile

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05613	GPA33 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GPA33	VGNC	VGNC:50186
Felis catus	GPA33	VGNC	VGNC:67400
Macaca mulatta	GPA33	VGNC	VGNC:106374
Canis familiaris	GPA33	VGNC	VGNC:53485
Mus musculus	GPA33	MGD	MGI:1891703
Rattus norvegicus	GPA33	RGD	RGD:1306711
Others	GPA33	NCBI

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