MC1R - melanocortin 1 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 102552838

About MC1R

Primary_assembly 19: 51,453,239-51,454,192 forward strand.mRatBN7.2:CM026992.1

This gene has 1 transcript (splice variant), 156 orthologues, 18 paralogues and is associated with 25 phenotypes.

Summary

Enables hormone binding activity and Melanocortin Receptor activity. Involved in positive regulation of feeding behavior. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

MC1R Products (1)

mRNA Protein Name
NM_001401091.1 NP_001388020.1 melanocortin 1 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables hormone binding IMP
IMP: Inferred from mutant phenotype
16454799 RGD
enables melanocortin receptor activity IMP
IMP: Inferred from mutant phenotype
16454799 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
16257393 RGD
involved in regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
19340414 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MC1R Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (38 - 308)

7tm_GPCRs

7tm_GPCRs: cd14964 (40 - 64)

7tm_GPCRs

7tm_GPCRs: cd14964 (73 - 95)

7tm_GPCRs

7tm_GPCRs: cd14964 (117 - 139)

7tm_GPCRs

7tm_GPCRs: cd14964 (162 - 178)

7tm_GPCRs

7tm_GPCRs: cd14964 (184 - 207)

7tm_GPCRs

7tm_GPCRs: cd14964 (239 - 261)

7tm_GPCRs

7tm_GPCRs: cd14964 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 317 a.a.
Protein Preferred Names Protein Names

melanocortin 1 receptor

melanocyte-stimulating hormone receptor

  • alpha melanocyte stimulating hormone receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19870 Setmelanotide Agonist 99.99% Yes
HY-N2466 Melanotan I Agonist 99.93% Unkown
HY-N2466A Melanotan I acetate Agonist 98.96% Unkown
HY-19870A Setmelanotide TFA Agonist / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107139 JNJ-10229570 Antagonist 98.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1726 MSG606 Antagonist 99.68% Unkown
HY-115644 BMS-470539 dihydrochloride Agonist 99.85% Unkown
HY-P0097A Nonapeptide-1 acetate salt Antagonist 95.58% Unkown
HY-P5247 Palmitoyl tetrapeptide-20 Activator 99.21% Unkown
HY-P0097 Nonapeptide-1 Antagonist 98.74% Unkown
HY-147301 Resomelagon Agonist 98.79% Unkown
HY-P1545A ACTH (1-17) TFA Agonist 99.79% Unkown
HY-P2336A CCZ01048 TFA 98.54% Unkown
HY-19870C Setmelanotide monoacetate Agonist 99.81% Unkown
HY-P5247A Palmitoyl tetrapeptide-20 TFA Activator / Unkown
HY-P99004 hMC1R agonist 1 Antagonist / Unkown
HY-168383 (E/Z)-Resomelagon acetate Agonist / Unkown
HY-P1726A MSG606 TFA Antagonist / Unkown
HY-111131 RY764 Agonist / Unkown
HY-125055A CD08108 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MC1R NCBI NCBI:4157