CLEC10A - C-type lectin domain containing 10A Gene

Also Known as HML; MGL; HML2; CD301; CLECSF13; CLECSF14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10462

About CLEC10A

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,074,537-7,080,251 (from NCBI)

This gene has 6 transcripts (splice variants), 148 orthologues and 14 paralogues. Broad expression in appendix (RPKM 13.9), small intestine (RPKM 10.3) and 21 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CLEC10A Products (3)

mRNA Protein Name
NM_001330070.2 NP_001316999.1 C-type lectin domain family 10 member A isoform 3
NM_006344.4 NP_006335.2 C-type lectin domain family 10 member A isoform 2
NM_182906.4 NP_878910.1 C-type lectin domain family 10 member A isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC10A Protein Structure

Lectin_N

Lectin_N: Hepatic lectin, N-terminal domain (7 - 128)

Lectin_C

Lectin_C: Lectin C-type domain (199 - 305)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 10 member A

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived)

CLEC10A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLEC10A Q8IUN9 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 GIMAP1 Homo sapiens Q8WWP7
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 GIMAP1 Homo sapiens Q8WWP7
Complementation
32296183
Intra
CLEC10A Q8IUN9 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 FAM241A Homo sapiens Q8N8J7
Anti Tag CoIP
33961781
Cross
CLEC10A Q8IUN9 S SARS-CoV-2 P0DTC2
Solution NMR
32915505
Intra
CLEC10A Q8IUN9 ACSF2 Homo sapiens Q96CM8
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra
CLEC10A Q8IUN9 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC10A Proteins

Cat. No. Product Name Accession Purity
HY-P72689 CLEC10A/CD301 Protein, Human (HEK293, His) Q8IUN9 (Q61-H316) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75676 CLEC10A/CD301 Protein, Human (HEK293, Fc) Q8IUN9-2 (Q61-H292) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18435 Clec10a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02779 CLEC10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24917 Clec10a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLEC10A VGNC VGNC:55799
Rattus norvegicus CLEC10A RGD RGD:621158
Macaca mulatta CLEC10A VGNC VGNC:71188
Others CLEC10A NCBI