MXD4 - MAX dimerization protein 4 Gene

Also Known as MAD4; MST149; MSTP149; bHLHc12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10608

About MXD4

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,247,432-2,262,109 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 22.9), spleen (RPKM 18.5) and 25 other tissues.

Summary

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]

MXD4 Products (1)

mRNA Protein Name
NM_006454.3 NP_006445.1 max dimerization protein 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15469726 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MXD4 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (55 - 106)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

max dimerization protein 4

  • Mad4 homolog

MXD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MXD4 Q14582 TCP10L Homo sapiens Q8TDR4
Confocal
15469726
Intra
MXD4 Q14582 TCP10L Homo sapiens Q8TDR4
Anti Tag CoIP
15469726
Intra
MXD4 Q14582 TCP10L Homo sapiens Q8TDR4
Y2H
15469726
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Extracranial Neuroblastoma
Bladder Sarcoma

  • Sarcoma Of Bladder

  • Sarcoma Of The Urinary Bladder
Corneal Dystrophy, Subepithelial Mucinous

  • Subepithelial Mucinous Corneal Dystrophy

  • SMCD
Williams-Beuren Syndrome

  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws
Nut Midline Carcinoma

  • Nuclear Protein In Testis Midline Carcinoma

  • Nmc
Cerebellar Medulloblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08863 MXD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MXD4 VGNC VGNC:107351
Mus musculus MXD4 MGD MGI:104991
Macaca mulatta MXD4 VGNC VGNC:100251
Bos taurus MXD4 VGNC VGNC:31772
Canis familiaris MXD4 VGNC VGNC:43514
Rattus norvegicus MXD4 RGD RGD:1305093
Others MXD4 NCBI