RAD51AP1 - RAD51 associated protein 1 Gene

Also Known as PIR51

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10635

About RAD51AP1

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,538,890-4,560,047 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 9.3), testis (RPKM 6.1) and 20 other tissues.

Summary

Enables nucleic acid binding activity. Involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Located in chromatin and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RAD51AP1 Products (3)

mRNA Protein Name
NM_001130862.2 NP_001124334.1 RAD51-associated protein 1 isoform a
NM_001410959.1 NP_001397888.1 RAD51-associated protein 1 isoform c
NM_006479.5 NP_006470.1 RAD51-associated protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-loop DNA binding IDA
IDA: Inferred from direct assay
17996711 GOA
enables DNA binding IDA
IDA: Inferred from direct assay
31253762 GOA
enables DNA secondary structure binding IDA
IDA: Inferred from direct assay
17996710 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
9396801 GOA
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
9396801 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9396801 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
9396801 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
17996710 GOA
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
23754376 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
26323318 GOA
involved in interstrand cross-link repair IMP
IMP: Inferred from mutant phenotype
26323318 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
17996710 GOA
involved in positive regulation of reciprocal meiotic recombination IDA
IDA: Inferred from direct assay
17996711 GOA
involved in regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
23754376 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
26323318 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26323318 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
16990250 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RAD51-associated protein 1

  • RAD51-interacting protein

RAD51AP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAD51AP1 Q96B01 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Prey Pooling
32296183
Intra
RAD51AP1 Q96B01 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11606 RAD51AP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19559 Rad51ap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26055 Rad51ap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAD51AP1 RGD RGD:1597431
Canis familiaris RAD51AP1 VGNC VGNC:45318
Bos taurus RAD51AP1 VGNC VGNC:58401
Macaca mulatta RAD51AP1 VGNC VGNC:76497
Mus musculus RAD51AP1 MGD MGI:1098224
Others RAD51AP1 NCBI