CAMKK2 - calcium/calmodulin dependent protein kinase kinase 2 Gene

Homo sapiens

Also known as CAMKK; CAMKKB

Gene ID: 10645 | Gene type: protein coding

About CAMKK2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,237,692-121,297,819 (from NCBI)

This gene has 17 transcripts (splice variants), 99 orthologues and 22 paralogues. Ubiquitous expression in brain (RPKM 24.4), spleen (RPKM 11.0) and 24 other tissues.

Summary

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

CAMKK2 Products(9)

mRNA	Protein	Name
NM_001270485.2	NP_001257414.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
NM_001270486.1	NP_001257415.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 7
NM_006549.4	NP_006540.3	calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
NM_153499.3	NP_705719.2	calcium/calmodulin-dependent protein kinase kinase 2 isoform 2
NM_153500.2	NP_705720.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 4
NM_172214.3	NP_757363.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 5
NM_172215.3	NP_757364.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 6
NM_172216.2	NP_757365.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 3
NM_172226.3	NP_757380.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

CAMKK2 Protein Structure

Pkinase

0
100
200
300
400
500
588 a.a.

Protein Preferred Names

Protein Names

calcium/calmodulin-dependent protein kinase kinase 2

CAMKK beta protein

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W017212	Methyl cinnamate		99.99%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-108458	SB 452533	Antagonist	98.92%	Unkown
HY-162009	CaMKK2-IN-1		/	Unkown
HY-163064	CC-3240	Inhibitor	/	Unkown
HY-RS01866	CAMKK2 Human Pre-designed siRNA Set A		/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown
HY-N8016S2	Nonanal-d2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CAMKK2	VGNC	VGNC:26726
Macaca mulatta	CAMKK2	VGNC	VGNC:99907
Felis catus	CAMKK2	VGNC	VGNC:60337
Mus musculus	CAMKK2	MGD	MGI:2444812
Rattus norvegicus	CAMKK2	RGD	RGD:620092
Canis familiaris	CAMKK2	VGNC	VGNC:38684

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