CAMKK2 - calcium/calmodulin dependent protein kinase kinase 2 Gene

Also Known as CAMKK; CAMKKB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10645

About CAMKK2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,237,692-121,297,819 (from NCBI)

This gene has 17 transcripts (splice variants), 99 orthologues and 22 paralogues. Ubiquitous expression in brain (RPKM 24.4), spleen (RPKM 11.0) and 24 other tissues.

Summary

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

CAMKK2 Products (9)

mRNA	Protein	Name
NM_001270485.2	NP_001257414.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
NM_001270486.1	NP_001257415.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 7
NM_006549.4	NP_006540.3	calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
NM_153499.3	NP_705719.2	calcium/calmodulin-dependent protein kinase kinase 2 isoform 2
NM_153500.2	NP_705720.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 4
NM_172214.3	NP_757363.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 5
NM_172215.3	NP_757364.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 6
NM_172216.2	NP_757365.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 3
NM_172226.3	NP_757380.1	calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	11395482	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	26103054	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	26103054	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11395482	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11395482	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IMP IMP: Inferred from mutant phenotype	26103054	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMKK2 Protein Structure

Pkinase

0
100
200
300
400
500
588 a.a.

Protein Preferred Names	Protein Names
calcium/calmodulin-dependent protein kinase kinase 2	CAMKK beta protein

CAMKK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81205	CAMKK2 Antibody	WB, IHC-P, IHC-F, FC,	Human, Mouse, Rat, Sheep

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W017212	Methyl cinnamate		99.95%	Unkown
HY-162009	CaMKK2-IN-1		98.32%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-163064	CC-3240	Degrader	99.24%	Unkown
HY-168905	SGC-CAMKK2-1	Inhibitor	98.80%	Unkown
HY-19870C	Setmelanotide monoacetate		99.81%	Unkown
HY-108458	SB 452533	Antagonist	99.11%	Unkown
HY-RS01866	CAMKK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-117356A	MRS2693 ammonium		/	Unkown
HY-E70813	CAMKK2 Recombinant Human Active Protein Kinase		/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown
HY-N8016S2	Nonanal-d2		/	Unkown
HY-RS17176	Camkk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23626	Camkk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W017212S	Methyl cinnamate-d7		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CAMKK2	VGNC	VGNC:26726
Macaca mulatta	CAMKK2	VGNC	VGNC:99907
Felis catus	CAMKK2	VGNC	VGNC:60337
Mus musculus	CAMKK2	MGD	MGI:2444812
Rattus norvegicus	CAMKK2	RGD	RGD:620092
Canis familiaris	CAMKK2	VGNC	VGNC:38684
Others	CAMKK2	NCBI