Glo1 - glyoxalase 1 Gene

Also Known as GLY1; Qglo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; 0610009E22Rik; 1110008E19Rik; 2510049H23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109801

About Glo1

Chromosome 17: 30,803,910-30,845,845 reverse strand.GRCm39:CM001010.3

This gene has 10 transcripts (splice variants), 263 orthologues, 1 paralogue and is associated with 5 phenotypes. Ubiquitous expression in liver adult (RPKM 62.5), liver E18 (RPKM 45.7) and 28 other tissues.

Summary

Enables lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]

Glo1 Products (2)

mRNA Protein Name
NM_001113560.1 NP_001107032.1 lactoylglutathione lyase
NM_025374.3 NP_079650.3 lactoylglutathione lyase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lactoylglutathione lyase activity IDA
IDA: Inferred from direct assay
566476 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
18695250 MGI
Biological Process GO Annotation Evidence References Source
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
18695250 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17670746 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Glo1 Protein Structure

PLN03042

PLN03042: PLN03042 (19 - 183)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

lactoylglutathione lyase

  • S-D-lactoylglutathione methylglyoxal lyase

  • aldoketomutase

  • glx I

  • glyoxalase 1 complex

  • glyoxalase 1 regulatory

  • glyoxalase 1 structural

  • glyoxalase I

  • ketone-aldehyde mutase

  • methylglyoxalase

Recombinant Glo1 Proteins

Cat. No. Product Name Accession Purity
HY-P75162 GLO1/Glyoxalase I Protein, Mouse (His) Q9CPU0/NP_079650.3 (A2-I184) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136684 BrBzGCp2 Inhibitor 99.00% Unkown
HY-W001288 Indole-4-carboxaldehyde 99.85% Unkown
HY-34005 2-Dimethylaminophenol Inhibitor / Unkown
HY-146655 Glyoxalase I inhibitor 3 Inhibitor 98.06% Unkown
HY-124824 Methyl gerfelin Inhibitor 99.9% Unkown
HY-146653 Glyoxalase I inhibitor 1 Inhibitor / Unkown
HY-146654 Glyoxalase I inhibitor 2 Inhibitor / Unkown
HY-146657 4BAB Inhibitor / Unkown
HY-RS05485 GLO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05486 Glo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05487 Glo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W001288S Indole-4-carboxaldehyde-13C / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glo1 NCBI NCBI:2739