GTF2A1L - general transcription factor IIA subunit 1 like Gene

Also Known as ALF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11036

Summary

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (Alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]
Biased expression in testis (RPKM 30.5), endometrium (RPKM 1.9) and 1 other tissue.

GTF2A1L Products (2)

mRNA Protein Name
NM_001193487.3 NP_001180416.1 TFIIA-alpha and beta-like factor isoform 2
NM_006872.5 NP_006863.2 TFIIA-alpha and beta-like factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cognition IMP
IMP: Inferred from mutant phenotype
23227193 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2A1L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GTF2A1L Q9UNN4 GAB1 Homo sapiens Q13480
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05892 GTF2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown