PRDM7 - PR/SET domain 7 Gene

Also Known as PFM4; ZNF910

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11105

About PRDM7

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:90,056,566-90,077,331 (from NCBI)

This gene has 5 transcripts (splice variants), 152 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a member of a family of proteins that may have roles in transcription and Other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a Histone Methyltransferase. [provided by RefSeq, Aug 2013]

PRDM7 Products (1)

mRNA Protein Name
NM_001098173.2 NP_001091643.1 histone-lysine N-methyltransferase PRDM7

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
27129774 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM7 Protein Structure

KRAB

KRAB: KRAB box (28 - 64)

SSXRD

SSXRD: SSXRD motif (170 - 202)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase PRDM7

  • PR domain 7

PRDM7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRDM7 Q9NQW5 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11071 PRDM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176820 MRK-740-NC Inhibitor / Unkown
HY-RS25719 Prdm9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRDM7 MGD MGI:2384854