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NUDT4 - nudix hydrolase 4 Gene

Also Known as DIPP2; NUDT4B; DIPP-2B; HDCMB47P; DIPP2beta; DIPP2alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11163

About NUDT4

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,377,925-93,408,146 (from NCBI)

This gene has 7 transcripts (splice variants), 294 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 30.0), kidney (RPKM 25.7) and 25 other tissues.

Summary

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each Other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

NUDT4 Products (5)

mRNA	Protein	Name
NM_001301022.2	NP_001287951.1	diphosphoinositol polyphosphate phosphohydrolase 2 isoform 3
NM_001301023.2	NP_001287952.1	diphosphoinositol polyphosphate phosphohydrolase 2 isoform 4
NM_001301024.2	NP_001287953.1	diphosphoinositol polyphosphate phosphohydrolase 2 isoform 4
NM_019094.6	NP_061967.3	diphosphoinositol polyphosphate phosphohydrolase 2 isoform alpha
NM_199040.4	NP_950241.1	diphosphoinositol polyphosphate phosphohydrolase 2 isoform beta

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables diphosphoinositol-polyphosphate diphosphatase activity	IDA IDA: Inferred from direct assay	10777568	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT4 Protein Structure

NUDIX

0
100
180 a.a.

Protein Preferred Names	Protein Names
diphosphoinositol polyphosphate phosphohydrolase 2	DIPP-2

NUDT4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUDT4	Q9NZJ9	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	NUDT4	Q9NZJ9	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	NUDT4	Q9NZJ9	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	NUDT4	Q9NZJ9	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	NUDT4	Q9NZJ9	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	NUDT4	Q9NZJ9	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	NUDT4	Q9NZJ9	KEAP1	Homo sapiens	Q14145	Validated Y2H	25416956
Intra	NUDT4	Q9NZJ9	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09672	NUDT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NUDT4	MGD	MGI:1918457
Rattus norvegicus	NUDT4	RGD	RGD:621355
Canis familiaris	NUDT4	VGNC	VGNC:58000
Others	NUDT4	NCBI