INMT - indolethylamine N-methyltransferase Gene

Also Known as TEMT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11185

About INMT

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,752,135-30,757,602 (from NCBI)

This gene has 4 transcripts (splice variants), 80 orthologues and 2 paralogues. Broad expression in lung (RPKM 67.4), adrenal (RPKM 18.7) and 14 other tissues.

Summary

N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and Other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and Other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]

INMT Products (2)

mRNA	Protein	Name
NM_001199219.2	NP_001186148.1	indolethylamine N-methyltransferase isoform 2
NM_006774.5	NP_006765.4	indolethylamine N-methyltransferase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amine N-methyltransferase activity	IDA IDA: Inferred from direct assay	10552930	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amine metabolic process	IDA IDA: Inferred from direct assay	10552930	GOA
involved in methylation	IDA IDA: Inferred from direct assay	10552930	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	10552930	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INMT Protein Structure

NNMT_PNMT_TEMT

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
indolethylamine N-methyltransferase	amine N-methyltransferase

INMT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INMT	O95050	KLHL12	Homo sapiens	Q53G59	Validated Y2H	25416956
Intra	INMT	O95050	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183
Intra	INMT	O95050	KLHL12	Homo sapiens	Q53G59	Y2H Array	25416956
Intra	INMT	O95050	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	INMT	O95050	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

INMT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810747	INMT Antibody (YA9990)	WB, ICC/IF	Human, Mouse, Rat
HY-P810751	INMT Antibody (YA9994)	WB, IHC-P	Human, Mouse
HY-P83356	INMT Antibody (YA3101)	WB	Mouse

Related Diseases

Diseases	Alias
Hallucinogen Abuse

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124101	PDAT	Inhibitor	98.0%	Unkown
HY-151193	NNMT-IN-3	Inhibitor	/	Unkown
HY-182021	NNMT-IN-8	Inhibitor	/	Unkown
HY-RS06820	INMT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22208	Inmt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28730	Inmt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	INMT	VGNC	VGNC:108416
Rattus norvegicus	INMT	RGD	RGD:1597087
Mus musculus	INMT	MGD	MGI:102963
Others	INMT	NCBI