WBP4 - WW domain binding protein 4 Gene

Also Known as FBP21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11193

About WBP4

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:41,061,509-41,084,006 (from NCBI)

This gene has 1 transcript (splice variant) and 204 orthologues. Ubiquitous expression in brain (RPKM 9.7), fat (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

WBP4 Products (1)

mRNA Protein Name
NM_007187.5 NP_009118.1 WW domain-binding protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables proline-rich region binding IPI
IPI: Inferred from physical interaction
19592703 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA cis splicing, via spliceosome IDA
IDA: Inferred from direct assay
19592703 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
19592703 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28781166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WBP4 Protein Structure

zf-U1

zf-U1: U1 zinc finger (8 - 43)

WW

WW: WW domain (126 - 153)

WW

WW: WW domain (169 - 194)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

WW domain-binding protein 4

  • WBP-4

WBP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WBP4 O75554 RBM45 Homo sapiens Q8IUH3
Anti Tag CoIP
33961781
Intra
WBP4 O75554 HTT Homo sapiens P42858
Y2H
17500595
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15752 WBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16877 Sf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown