PTH2 - parathyroid hormone 2 Gene

Also Known as TIP39

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113091

About PTH2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,422,419-49,423,441 (from NCBI)

This gene has 1 transcript (splice variant) and 150 orthologues.

Summary

This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary Hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]

PTH2 Products (1)

mRNA Protein Name
NM_178449.4 NP_848544.1 tuberoinfundibular peptide of 39 residues preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTH2 Protein Structure

TIP39

TIP39: TIP39 peptide (49 - 99)

  • 0
  • 100 a.a.
Protein Preferred Names Protein Names

tuberoinfundibular peptide of 39 residues

  • tuberoinfundibular 39 residue protein

PTH2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTH2 Q96A98 AMD1 Homo sapiens P17707
Anti Tag CoIP
33961781
Intra
PTH2 Q96A98 AMD1 Homo sapiens P17707
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polyomavirus-Associated Nephropathy

  • Polyomavirus Associated Nephropathy

  • Pvan
Benign Chronic Pemphigus

  • Hailey-Hailey Disease

  • Pemphigus, Benign Familial

  • Familial Benign Pemphigus

  • Benign Familial Pemphigus

  • Familial Benign Chronic Pemphigus

  • BCPM

  • HHD

  • Benign Chronic Familial Pemphigus Of Hailey-Hailey

  • Pemphigus, Chronic, Benign
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1852 TIP 39, Tuberoinfundibular Neuropeptide 99.84% Unkown
HY-P4835 pTH (2-34) (human) / Unkown
HY-RS11396 PTH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11397 PTH2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11454 PTRH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20090 Pth2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20092 Ptrh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26593 Pth2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PTH2 VGNC VGNC:64429
Rattus norvegicus PTH2 RGD RGD:1559447
Bos taurus PTH2 VGNC VGNC:33515
Mus musculus PTH2 MGD MGI:2152297
Canis familiaris PTH2 VGNC VGNC:45155
Macaca mulatta PTH2 VGNC VGNC:76577
Others PTH2 NCBI