ECD - ecdysoneless cell cycle regulator Gene

Also Known as GCR2; SGT1; HSGT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11319

About ECD

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,133,668-73,168,095 (from NCBI)

This gene has 8 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 14.0), thyroid (RPKM 12.4) and 25 other tissues.

Summary

Enables Histone Acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ECD Products (3)

mRNA Protein Name
NM_001135752.1 NP_001129224.1 protein ecdysoneless homolog isoform 2
NM_001135753.1 NP_001129225.1 protein ecdysoneless homolog isoform 3
NM_007265.3 NP_009196.1 protein ecdysoneless homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone acetyltransferase binding IDA
IDA: Inferred from direct assay
19919181 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23880345 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19919181 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19919181 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19919181 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECD Protein Structure

SGT1

SGT1: SGT1 protein (13 - 597)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 644 a.a.
Protein Preferred Names Protein Names

protein ecdysoneless homolog

  • ecdysoneless homolog

ECD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ECD O95905 TXNIP Homo sapiens Q9H3M7
Pull Down
23880345
Intra
ECD O95905 TXNIP Homo sapiens Q9H3M7
Anti Bait CoIP
23880345
Intra
ECD O95905 TXNIP Homo sapiens Q9H3M7
Anti Tag CoIP
23880345
Intra
ECD O95905 RUVBL1 Homo sapiens Q9Y265
TAP
26711270
Intra
ECD O95905 RUVBL1 Homo sapiens Q9Y265
Pull Down
26711270
Intra
ECD O95905 RUVBL1 Homo sapiens Q9Y265
Anti Bait CoIP
26711270
Intra
ECD O95905 PIH1D1 Homo sapiens Q9NWS0
Anti Tag CoIP
24656813
Intra
ECD O95905 PIH1D1 Homo sapiens Q9NWS0
Anti Bait CoIP
26711270
Intra
ECD O95905 PIH1D1 Homo sapiens Q9NWS0
Pull Down
26711270
Intra
ECD O95905 PIH1D1 Homo sapiens Q9NWS0
Pull Down
24656813
Intra
ECD O95905 PRPF8 Homo sapiens Q6P2Q9
Anti Bait CoIP
26711270
Intra
ECD O95905 PRPF8 Homo sapiens Q6P2Q9
TAP
26711270
Intra
ECD O95905 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
33961781
Intra
ECD O95905 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ECD Proteins

Cat. No. Product Name Accession Purity
HY-P74182 ECD Protein, Human (sf9, His-GST) O95905-1 (M1-N644) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cerebral Primitive Neuroectodermal Tumor

  • Pnet Of Cerebrum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99380 Zanidatamab Inhibitor 98.56% Unkown

Clinical Phase

Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P991332 JAB-BX102 Inhibitor / Phase 2
HY-P991572 MM-151 Antagonist / Phase 2
HY-P991330 BMS-986179 Inhibitor / Phase 2
HY-P991443 IPH5301 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18377 Bioymifi 98.00% Unkown
HY-P10495 GPR110 peptide agonist P12 Activator / Unkown
HY-185816 TQB2102 Inhibitor / Unkown
HY-N20678 Hupehenoside A / Unkown
HY-RS04132 ECD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12649 SEM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0828S Triazophos-d5 Inhibitor / Unkown
HY-RS17935 Ecd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24405 Ecd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990957 Ficerafusp alfa Inhibitor 99.71% Unkown
HY-P990903 Avitotamig Inhibitor 95.98% Unkown
HY-P99963 Sudubrilimab Inhibitor ≥99.0% Unkown
HY-P991239 NM-02 Inhibitor / Unkown
HY-P991465 Anti-CD27 Antibody (M2177) Inhibitor / Unkown
HY-P991466 Anti-CD27 Antibody (M2191) Inhibitor / Unkown
HY-P992341 D8P1C1 Inhibitor / Unkown
HY-P992481 VERT-002 Degrader / Unkown
HY-P991331 BC-010 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ECD VGNC VGNC:71852
Rattus norvegicus ECD RGD RGD:1565023
Canis familiaris ECD VGNC VGNC:40180
Felis catus ECD VGNC VGNC:61706
Bos taurus ECD VGNC VGNC:28301
Mus musculus ECD MGD MGI:1917851
Others ECD NCBI